Project description:There is already strong evidence indicating that different types of non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs, are key players in the regulation of β-cell functions and in the development of diabetes. However, the role of the newly discovered class of circular RNAs remains to be elucidated. We therefore analysed circular RNA expression in human islet samples.
Project description:To identify novel circular RNAs (circRNAs) and to investigate their expression levels during human pluripotent stem cells (hiPSC) differentation, we have converted these cells to vascular endothelial cells (ECs) and smooth muscle cells (SMCs). Circular RNAs were de novo identified using RNase R treated samples and quantified in total RNA samples at 13 timepoints per differentiation.
Project description:To further explore the expression of circular RNAs in keloid,we have completed the Arraystar Human circRNA Array V2 analysis of the 8 samples,including 4 patients-derived keloid dermal fibroblasts and 4 normal dermal fibroblasts.
Project description:To explore the potential involvement of circular RNAs (circRNAs) in pancreatic ductal adenocarcinoma (PDAC) oncogenesis, we conducted circRNA profiling in six pairs of human PDAC and adjacent normal tissue by microarray. Our results showed that clusters of circRNAs were aberrantly expressed in PDAC compared with normal samples, and provided potential targets for future treatment of PDAC and novel insights into PDAC biology. Analyze circular RNA expression in pancreatic ductal adenocarcinoma (PDAC) by microarray platform.
Project description:Background: Non-coding circular RNAs (circRNAs) have displayed dysregulated expression in several human cancers. Here, we profiled the circRNA expression of papillary thyroid carcinoma (PTC) tumors to improve our understanding of PTC pathogenesis as well as to identify potential circRNA biomarkers for PTC.