Project description:A single-centre, randomized, 2-arm clinical trial comparing follow-up consisting of tumour-specific Electronic Patient-Reported Outcomes (ePROs) with targeted symptom management versus standard of care follow-up during neoadjuvant/adjuvant systemic therapy

| 2385533 | ecrin-mdr-crc

Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)

Project description:This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer patients and caregivers during post-treatment care transition.

| 2347191 | ecrin-mdr-crc

Self-Reported Race as a Determinant of Differential Methylation in Peripheral Artery Disease

Project description:Peripheral Artery Disease (PAD) is a manifestation of atherosclerosis within the lower extremities that affects approximately 10 million people in the United States. Despite the rising prevalence of PAD, Black Americans are disproportionately affected and experience worse outcomes, including higher rates of limb loss compared to White counterparts. To dissect mechanisms within PAD, we performed DNA methylation analysis utilizing methyl-binding domain-capture sequencing. Within the DNA methylation profiles, we observe a large driver of variation is self-reported race. Specifically, samples separate into White and Black groups. Interestingly, when comparing PAD to Control samples within each self-reported racial group, there are different differentially methylated CpGs between the two groups. This suggests that the methylation landscape both at baseline and in disease is different based on self-reported racial background and could begin to explain some of the differences we see in downstream outcomes between White and Black Americans.

2025-12-04 | GSE289487 | GEO

Evaluating the Use of Patient-Reported Outcome Measures for Improving the Inter-Rater Reliability of Common Terminology Criteria for Adverse Event Ratings

Project description:This open randomized trial investigates, if clinicians complete CTCAE ratings differently when receiving patients’ patient-reported outcome (PRO) data prior to their CTCAE completion. The primary objective is to demonstrate superior inter-rater reliability of CTCAE ratings from physicians relying on EORTC PRO data as additional data source over traditional CTCAE ratings not including PRO information.

| 2314534 | ecrin-mdr-crc

A Period1 inducer specifically advances circadian clock in mice

Project description:A Period1 inducer specifically advances circadian clock in mice

| PRJNA1276469 | ENA

Patient-Reported Outcomes in Long-Term Survivors of Colon and Rectal Cancers

Project description:RATIONALE: Learning about quality of life, symptoms, and health behaviors in colorectal cancer survivors may help to determine the long-term effects of colon and rectal cancer treatments and may help to improve the quality of life for future cancer survivors. PURPOSE: This clinical trial is looking at patient-reported outcomes in long-term survivors of colon and rectal cancers.

| 2035263 | ecrin-mdr-crc

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