Project description:THE TITLE COMPOUND [SYSTEMATIC NAME: (9-meth-oxy-3,5-dimethyl-5,6-dihydro-naphtho-[2,3-b]furan-4-yl)methyl 2-meth-yl-but-2-enoate], C(21)H(24)O(4), was isolated from matarique, or Psacalium peltatum (Kunth). The structure is almost planar. The angelo-yloxy group makes an angle of 62.08 (2)° with the furan-oeremophilane skeleton. The carbonyl O atom is disordered between two positions with a 76:24 ratio. The mol-ecules in the crystal are joined by very weak C-H-O inter-actions in the ac plane.
| S-EPMC3295460 | biostudies-literature
Project description:Amplicon sequencing of Podophyllum hexandrum
Project description:Primary objectives: The primary objective is to investigate circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Primary endpoints: circulating tumor DNA (ctDNA) via deep sequencing for mutation detection and by whole genome sequencing for copy number analyses before start (baseline) with regorafenib and at defined time points during administration of regorafenib for treatment efficacy in colorectal cancer patients in terms of overall survival (OS).
Project description:With the aim of reveal the mechanism of Podophyllum Hexandrum Royle adaption to high altitude, MALDI-TOF-MS/MS in combination with 2-DE was used to identify the differentially expressed proteins in leaves of Podophyllum Hexandrum Royle between low altitude (2200m) and high altitude (3100m), 65 differentially expressed proteins was identifed and 44 was up-regulated in high altitude compared tolow altitude.
