Project description:Wound healing is one fundamental physiological process which maintains the integrity of skin through a series of well-orchestrated biological and molecular events,effective resolution of inflammation is crucial for wound healing We used microarrays to characterize molecular mechanisms of wound healing with Spink7 KO mice of up-regulated genes during this process.
Project description:To investigate the effect of iNKT deficiency in the skin, the analysis of global gene expression in the skin tissues from WT and Cd1d KO mice were performed using RNA-seq data obtained from these samples.
Project description:Keratinocyte-specific RIPK1 deficiency causes skin inflammation due to ZBP1-induced necroptosis. RNA-Seq analysis of the skin from wild type and RIK1E-KO mice was performed to examine how RIPK1 deficiency affects the expression of mRNAs as well as endogenous retroelement-derived transcripts.
Project description:Skin aging is one of the hallmarks of the aging process that causes physiological and morpho-logical changes. Recently, several nutritional studies were conducted to delay or suppress the aging process. This study investigated whether nutritional supplementation of the eggshell membrane (ESM) has a beneficial effect on maintaining skin health and improving the skin aging process in interleukin-10 knockout (IL-10 KO) mice. Oral supplementation of 8% powdered-ESM (pESM) upregulated the expression of growth factors, including transforming growth factor β1, platelet-derived growth factor-β and connective tissue growth factor, and suppressed skin thinning.