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Plasma transcriptome profile in patients with mild traumatic brain injury

ABSTRACT: Plasma transcriptome profile in patients with mild traumatic brain injury

PROVIDER: PRJNA419819 | ENA |

REPOSITORIES: ENA

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Plasma transcriptome profile in patients with mild traumatic brain injury

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Microglia adopt longitudinal transcriptional changes after traumatic brain injury

Project description:Traumatic brain injury (TBI) is an under-recognizedpublic healththreat. Even mild brain injuries can lead to long-term neurologic impairment.Microgliaplay a fundamental role in the development and progression of this ensuing neurologic impairment. Despite this, a microglia-specific injury signature has yet to be identified. We hypothesized that TBI would lead to long-term changes in the transcriptional profile of microglial pathways associated with the development of subsequent neurologic impairment.

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2011-04-06 | E-GEOD-21854 | biostudies-arrayexpress

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