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Transcriptomes of human monocytes after ex vivo exposure to uric acid

ABSTRACT: Transcriptomes of human monocytes after ex vivo exposure to uric acid

PROVIDER: PRJNA421491 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6359080.fastq.gz	Fastqsanger.gz
	SRR6359090.fastq.gz	Fastqsanger.gz
	SRR6359081.fastq.gz	Fastqsanger.gz
	SRR6359091.fastq.gz	Fastqsanger.gz
	SRR6359082.fastq.gz	Fastqsanger.gz

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Transcriptomes of human monocytes after ex vivo exposure to uric acid

Project description:Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components. In this study we exposed monocytes from healthy donors to uric acid ex vivo, and analyzed the effect of this exposure on gene expression changes. After 'uric acid' or 'media only' treatments, monocytes were exposed to LPS for 4 hours to measure they response to this pyrogen.

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Project description:The effect of uric acid on islet function remains to be confirmed,We applied GSIS, immunofluorescence staining, WB, and flow cytometry to observe the protective effects of uric acid on beta cell apoptosis and insulin deficiency.To further explore the molecular mechanisms involved in this,we found UA could directly suppressed GSIS in both INS-1E cells and primary isolated islets in a dose- and time-dependent manner. RNAseq suggested that CHOP/NLRP3 is critical in the UA-induced beta cell dysfunction. These data suggest that UA might be an independent risk factor for beta cell function which induced beta cell dysfunction via OAT2/chop/ NLRP3 pathway. which provided new insight into the diabetogenic effect of UA.

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