Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Whole Exome Sequencing

ABSTRACT: Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Whole Exome Sequencing

PROVIDER: PRJNA422328 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Whole Exome Sequencing

Project description:Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Whole Exome Sequencing

| PRJNA422327 | ENA

Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Admixture Mapping

Project description:Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Admixture Mapping

| PRJNA416161 | ENA

Multi-omic Signatures of Host Response Associated with Presence, Type, and Outcome of Enterococcal Bacteremia metabolomics data

Project description:Meatbolomics data from the manuscript Multi-omic Signatures of Host Response Associated with the Presence, Type, and Outcome of Enterococcal Bacteremia.

2024-12-24 | MSV000096729 | MassIVE

Multi-omic Signatures of Host Response Associated with Presence, Type, and Outcome of Enterococcal Bacteremia proteomics data

Project description:Proteomics data from the manuscript Multi-omic Signatures of Host Response Associated with the Presence, Type, and Outcome of Enterococcal Bacteremia.

2024-12-24 | MSV000096728 | MassIVE

GNPS - Multi-omic Signatures of Host Response Associated with Presence, Type, and Outcome of Enterococcal Bacteremia metabolomics data

Project description:Meatbolomics data from the manuscript Multi-omic Signatures of Host Response Associated with the Presence, Type, and Outcome of Enterococcal Bacteremia.

2024-12-24 | MSV000096729 | GNPS

Homo sapiens

Project description:Host Genetic Determinants of the Outcome of Staphyloccus Aureus Bacteremia by Admixture Mapping

| PRJNA399609 | ENA

Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia

Project description:Persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia is life-threatening and occurs in up to 30% of MRSA bacteremia cases despite appropriate antimicrobial therapy. Isolates of MRSA that cause antibiotic-persistent MRSA bacteremia (APMB) typically have in vitro antibiotic susceptibilities equivalent to those causing antibiotic-resolving MRSA bacteremia (ARMB). Thus, persistence reflects host-pathogen interactions occurring uniquely in context of antibiotic therapy in vivo. However, host factors and mechanisms involved in APMB remain unclear. We compared DNA methylomes in circulating immune cells from patients experiencing APMB vs. ARMB. Overall, methylation signatures diverged in the distinct patient cohorts. Differentially methylated sites intensified proximate to transcription factor binding sites, primarily in enhancer regions. In APMB patients, significant hypo-methylation was observed in binding sites for CCAAT enhancer binding protein (C/EBP) and signal transducer / activator of transcription 1 (STAT1). In contrast, hypo-methylation in ARMB patients localized to glucocorticoid receptor and histone acetyltransferase p300 binding sites. These distinct methylation signatures were enriched in neutrophils and achieved a mean area under the curve of 0.85 when used to predict APMB using a classification model. These findings differentiate epigenotypes in patients experiencing APMB vs. ARMB, and suggest a risk stratification strategy for antibiotic persistence in patients treated for MRSA bacteremia.

2021-03-01 | GSE150144 | GEO

Construction of immune profiles in PBMC of bacteremia mice with different outcomes

Project description:We used mice as an experimental model to establish two animal infection models of bacteremia with different outcomes. In the low-dose infection group, the bacteria within the mice are cleared by the immune system, allowing the mice to survive. In contrast, the high-dose infection group leads to sepsis and ultimately results in the death of the mice. We aim to utilize single-cell sequencing technology to study the changes in the transcriptomes of various immune cells during different stages and outcomes of mammalian bacteremia, in order to understand the host's response to bacteremia.

2025-10-10 | GSE278240 | GEO

Analysis of bacteremia after endoscopic submucosal dissection of the colon using molecular biological technique.

Project description:Interventions: Analysis of bacteremia after ESD of the colon. Primary outcome(s): Identification of bacteremia after ESD testing blood culture and 16SrRNA gene sequencing. Study Design: Single arm Non-randomized

| 2623655 | ecrin-mdr-crc

Host Genetic Determinants of the Outcome of SAB by WES

Project description:In this case-control study, Complicated Staphylococcus aureus (case) is defined as bacteremia plus endocarditis or bone/joint infection, and Uncomplicated Staphylococcus aureus (control) has no such complications and was cured at follow-up. We used whole exome sequencing to examine the cumulative effect of coding variants in each gene on risk of complicated SAB in a discovery sample of 168 SAB cases (84 Complicated SAB and 84 Uncomplicated SAB, frequency matched by age, sex and bacterial clonal complex). Then we evaluated the 334 most significantly associated genes and 8 biological candidate genes in a replication sample of 240 SAB cases (122 complicated and 118 uncomplicated, frequency matched by age, sex and bacterial clonal complex). All participants were white, non-Hispanic of European descent. In the discovery sample, gene-based analysis using SKAT-O identified 334 genes associated with complicated SAB at p<3.5 x 10-3;. Gene-based analysis of the 342 genes in the replication sample using SKATO identified one gene, GLS2 (<a href="https://www.ncbi.nlm.nih.gov/gene/?term=GLS2">GeneID: 27165</a>), significantly associated with complicated SAB (p=1.2 x10-4;) after Bonferroni correction. GLS2 is an interesting candidate gene for complicated SAB due to its role in regulating glutamine metabolism, a key factor in white blood cell proliferation and activation.

| phs001505 | dbGaP

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data