Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

ABSTRACT: Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

PROVIDER: PRJNA428984 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Systemic post-translational control of bacterial metabolism regulates adaptation in dynamic environments

Project description:E. coli K-12 MG1655 was grown on M9 minimal media supplemented with 0.2% w/v glucose, fructose, or acetate. The goal of this study was to determine differentially expressed genes in the different media conditions.

2018-02-02 | GSE108871 | GEO

Bacterial rapid adaptation to alkaline environments

Project description:Bacterial rapid adaptation to alkaline environments

| PRJNA1125898 | ENA

Adaptation dynamics in stressful environments

Project description:Adaptation dynamics in stressful environments from standing genetic variation in S. cerevisiae

| PRJEB46680 | ENA

Protein Kinase A Regulates Gene-Specific Translational Adaptation in Differentiating Yeast

Project description:Cellular differentiation is driven by coordinately regulated changes in gene expression. Translational control of gene expression is increasingly recognized as pervasive and quantitatively significant, but the mechanisms responsible for widespread changes in gene-specific translation activity are largely unknown. Here we investigate the mechanisms responsible for translational reprogramming during cellular adaptation to the absence of glucose, a stimulus that induces invasive filamentous differentiation in yeast. We show that gene-specific translation efficiencies are highly adapted to cellular conditions and that glucose withdrawal is accompanied by widespread translational reprogramming at the level of translation initiation. We demonstrate that transcripts from <5% of genes make up the majority of translating mRNA in both rapidly dividing and starved cells. Moreover, the identities of these highly translated genes are growth-state specific, and they are subject to condition-dependent translational privilege. By comparing glucose starvation to other growth-attenuating stresses, we distinguish a glucose-specific translational response that regulates ribosomal protein and mitochondrial protein-coding genes. This response is mediated through signaling by protein kinase A (PKA). These findings reveal a high degree of growth-state specialization of the translatome and identify PKA as an important regulator of gene-specific translation activity. Examine translational adaptation in yeast in response to glucose starvation

2014-04-25 | E-GEOD-51532 | biostudies-arrayexpress

Systemic acquired adaptation induced by mito-stress (WGBS)

Project description:Systemic acquired adaptation (SAA) is a necessary biological process for plants to survive under abiotic stress. it can quickly transmit local stress to the whole body through signals such as reactive oxygen species and calcium ions and form a defense response. Recently, we have found that mitochondrial stress caused by mitochondrial translation inhibitor doxycycline can induce plant to form systemic acquired adaptation (Mito-SAA). We will further explore its molecular mechanism through multiomics and molecular biology.

2026-02-28 | GSE225961 | GEO

Systemic acquired adaptation induced by mito-stress (RNA-Seq)

2026-02-28 | GSE225960 | GEO

Systemic acquired adaptation induced by mito-stress (WGBS)

Project description:Systemic acquired adaptation induced by mito-stress (WGBS)

| PRJNA938109 | ENA

Systemic acquired adaptation induced by mito-stress (RNA-Seq)

Project description:Systemic acquired adaptation induced by mito-stress (RNA-Seq)

| PRJNA938110 | ENA

Plant 22-nt siRNAs mediate translational repression and stress adaptation

Project description:Plant 22-nt siRNAs mediate translational repression and stress adaptation

| PRJNA561412 | ENA