Project description:Malania oleifera Chun et S.K. Lee is a woody oil tree species and is rich in nervonic acid, which is associated with brain development. The variation in fatty acid composition and its response to environmental factors in natural populations has not been well studied. A total of 97 mature fruiting individuals were sampled from seven natural populations in Guangxi and Yunnan provinces, China. The fatty acid content (FAC) was 53.85%. Thirteen fatty acid components were identified. Nervonic acid (NVA), octadecenoic acid (OEA) and docosenoic acid (DSA) were the top three, averaging 45.68%, 30.21% and 14.03% of the FAC, respectively; the saturated fatty acid and unsaturated fatty acid contents were 4.82% and 95.18%, respectively. Coefficients of variation were low to moderate (7.64-18.42%) and Shannon-Wiener indices were moderate to high (1.80-2.04) for FAC, NVA, OEA and DSA. Significant variation between populations was observed for all traits, explaining 62.83%, 40.54%, 21.98% and 32.85% of the variance for FAC, NVA, OEA and DSA, respectively. The strong collinearity among traits summarized them into three principal components. FAC was positively correlated with NVA and NVA was negatively correlated with OEA and DSA at both the population and phenotypic levels. This pattern was significantly divergent from those documented in tree species with low NVA yields. The production of FAC and NVA is facilitated by elevated temperatures and reduced relative humidity. These findings provide a foundation for genetic improvement, industrial exploitation, resource management, and sustainable development of this species.

| S-EPMC11748571 | biostudies-literature

Malania oleifera cultivar:suntouguo

Project description:Malania oleifera genome sequencing

| PRJNA429683 | ENA

Effects of Malania oleifera Chun Oil on the Improvement of Learning and Memory Function in Mice

Project description:Background The fruits of Malania oleifera Chun & S. K. Lee have been highly sought after medically because its seeds have high oil content (>60%), especially the highest known proportion of nervonic acid (>55%). Objective of the Study. The objective was to explore the effects of different doses of Malania oleifera Chun oil (MOC oil) on the learning and memory of mice and to evaluate whether additional DHA algae oil and vitamin E could help MOC oil improve learning and memory and its possible mechanisms. Methods After 30 days of oral administration of the relevant agents to mice, behavioral tests were conducted as well as detection of oxidative stress parameters (superoxide dismutase, malondialdehyde, and glutathione peroxidase) and biochemical indicators (acetylcholine, acetyl cholinesterase, and choline acetyltransferase) in the hippocampus. Results Experimental results demonstrated that MOC oil treatment could markedly improve learning and memory of mouse models in behavioral experiments and increase the activity of GSH-PX in hippocampus and reduce the content of MDA, especially the dose of 46.27?mg/kg. The addition of DHA and VE could better assist MOC oil to improve the learning and memory, and its mechanism may be related to the inhibition of oxidative stress and restrain the activity of AChE and also increase the content of ACh. Conclusion Our results demonstrated that MOC oil treatment could improve learning and memory impairments. Therefore, we suggest that MOC oil is a potentially important resource for the development of nervonic acid products.

| S-EPMC7519201 | biostudies-literature

Anaerostipes hominis (ex Lee et al. 2021) strain:BG01

Project description:Anaerostipes hominis (ex Lee et al. 2021) strain:BG01 Genome sequencing and assembly

| PRJNA397540 | ENA