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Transcriptome of Dp1Tyb and wild-type mouse hippocampus

ABSTRACT: Transcriptome of Dp1Tyb and wild-type mouse hippocampus

PROVIDER: PRJNA430369 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6497330_1.fastq.gz	Fastqsanger.gz
	SRR6497330_2.fastq.gz	Fastqsanger.gz
	SRR6497331_1.fastq.gz	Fastqsanger.gz
	SRR6497331_2.fastq.gz	Fastqsanger.gz
	SRR6497341_1.fastq.gz	Fastqsanger.gz

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Project description:Embryos from the Dp1Tyb mouse model for Down syndrome (DS) present with congenital heart defects similar to the heart defects seen in humans with DS. We found that genetically reducing the copy number of the Dyrk1a gene (one of the genes in 3 copies in DS) from 3 to 2, normalised some of the transcriptomic changes in Dp1Tyb embryonic hearts and rescued congenital heart defects. Here we treated pregnant mice carrying Dp1Tyb and wild-type (WT) embryos with a Dyrk1a pharmacological inhibitor (Leucettinib-21 or L21) or an inactive isomer (Iso-L21) to study the effect of L21 on the transcriptome of Dp1Tyb and WT embryonic hearts.

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