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Ganoderma sinense

ABSTRACT: A basidiomycete fungus used in Chinese herbal medicine

PROVIDER: PRJNA43103 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR1562261.fastq.gz	Fastqsanger.gz
	SRR21616320_1.fastq.gz	Fastqsanger.gz
	SRR21616320_2.fastq.gz	Fastqsanger.gz
	SRR927381.fastq.gz	Fastqsanger.gz

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New alkaloids from the fruiting bodies of Ganoderma sinense

Project description:Four new alkaloids, sinensines B–E (1–4), together with one known alkaloid, sinensine (5), were isolated from the fruiting bodies of Ganoderma sinense. Their structures were elucidated on the basis of 1D and 2D NMR spectra analysis. The structure of sinensine E was confirmed by X-ray crystallographic analysis of its acetyl product (4a). Electronic Supplementary Material Supplementary material is available for this article at 10.1007/s13659-011-0026-4 and is accessible for authorized users.

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Project description:Personalized therapy of rheumatoid arthritis (RA) based on traditional Chinese medicine cold and hot syndromes is selection of the best treatment for an individual patient. Wutou Decoction (WTD) is one of the classic Chinese herbal formulae which achieve favorable therapeutic response in treating RA-cold syndrome. Microarray analysis based on the adjuvant induced arthritis model combined with characteristics of RA and cold/hot syndromes was performed to screen RA-cold and RA-hot-syndrome-related genes, as well as WTD effect genes.

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Efficacy and Safety Evaluation of Traditional Chinese Medicine in the Treatment of Advanced Colorectal Cancer

Project description:Although patients of colorectal cancer use Traditional Chinese Medicine (TCM) herbal therapy extensively in China, no strong evidence exists to demonstrate the safety and survival outcomes of TCM herbal therapy combined with conventional western medicine for treatment of this disease. The purpose of this multi-center perspective cohort study is to evaluate the relationship between TCM herbal therapy and survival outcomes in patients with advanced colorectal cancer.

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Integrated analysis reveals effects of bioactive ingredients from Limonium Sinense (Girard) Kuntze on hypoxia-inducible factor (HIF) activation

Project description:Limonium Sinense (Girard) Kuntze is a traditional Chinese medicinal herb, showing blood replenishment, anti-tumour, anti-hepatitis, and immunomodulation activities amongst others. However, the mechanism of its pharmacological activities remains largely unknown. Here, we investigated the effects of bioactive ingredients from Limonium Sinense using integrated analysis. Water extracts from Limonium Sinense (LSW) showed a strong growth inhibitory effect on multiple cells in both 2D and 3D cultures. Global transcriptomic profiling and further connectivity map (CMap) analysis identified several similarly acting therapeutic candidates, including Tubulin inhibitors and hypoxia-inducible factor (HIF) modulators. The effect of LSW on cell cycle was verified with flow cytometry showing a G2/M phase arrest. Integrated analysis suggested a role for gallic acid in mediating HIF activation. Taken together, this study provides novel insights into the bioactive ingredients in Limonium Sinense, highlighting the rich natural resource and therapeutic values of herbal plants.

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