Liver metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA431685 | ENA |
REPOSITORIES: ENA
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2025-06-15 | GSE298403 | GEO
Project description:Dietary intake of fruits and vegetables (FV) has been inversely associated with lower risk of ulcerative colitis. A pig model was used to evaluate the impact of feeding FV on the host response to dextran sulfate sodium (DSS)-induced colitis. Methods: Six-week-old pigs were fed a grower diet alone or supplemented with lyophilized FV equivalent to the half (half-FV) or full (full-FV) daily levels recommended for humans by the Dietary Guidelines for Americans (DGA). Pigs were fed a 1) grower diet alone (negative control), 2) grower diet and orally treated with 4% DSS for 10 days to induce colitis (positive control), 3) half-FV diet treated with 4% DSS or 4) full-FV diet treated with 4% DSS. Pigs were monitored for the development of clinical signs of colitis. Proximal colon (PC) contents and mucosa (PCM) were collected for gut metagenome, tissue transcriptome and histopathological analysis. Results: Pigs fed the full-FV diet did not exhibit diarrhea, showed less fecal occult blood (FOB), PCM crypt hyperplasia but with no differential expressed genes (DEG) or changes in PC microbiome diversity (p < 0.05). Pigs within the half-FV group exhibited increased group FOB and DEG associated with tissue remodeling, crypt and goblet cell hyperplasia in the PCM and no changes in PC microbiome diversity and two pigs exhibiting diarrhea (p < 0.05). Pigs within the DSS positive control group exhibited a reduced DEG involved with intestinal immune response and PC microbiome diversity with altered metagenome, increased group PCM erosion and FOB with persistent diarrhea in one pig (p < 0.05) Conclusions: Overall, our results showed that pigs fed a three-week full-FV supplemented diet, were resistant to DSS-induced colitis with a differential dose-dependent protective effect on host intestinal tissue and gut metagenome when exposed to an inflammatory challenge.
2026-04-01 | GSE317287 | GEO
Project description:We aim to study the unusual TMA metabolism mechanism of ducks, and further explore the hidden reasons that led to the weakening TMA metabolism ability. To achieve this, transcriptome, proteome, and metagenome analyses were integrated based on the constructed duck populations with high TMA metabolism ability and low TMA metabolism ability. In addition, further experiments were followed to validate the hypothesis on the limited flavin-containing monooxygenase 3 (FMO3) metabolism ability of ducks. The study demonstrated that both cecal microbe, including Akkermansia and Mucispirillum, and liver FMO3 participated in the TMA metabolism process of ducks. The limited oxidation ability of FMO3 explained the weakening TMA metabolism ability of ducks. Nevertheless, it contributed to the duck’s survival and reproduction during the evolutional adaption process.
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Project description:liver metagenome breed:Dorper crossbred Raw sequence reads
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Project description:The coordination of cell proliferation, polarization, and maturation with architectural assembly is crucial for liver development and regeneration, yet the mechanisms underlying this coordination remain unclear. Using both murine and human models, we demonstrate that hepatic cell polarity and bile canaliculi (BC) formation initiate at sites of cell division during the hepatoblast stage, while BC elongation occurs following hepatocyte differentiation. This elongation requires suppression of ERK/MAPK activity mediated by PAR3 and YAP. PAR3 interacts with a complex network of proteins, including IQGAP1, at tight junctions, thereby sequestering IQGAP1 from basolateral membranes where it typically promotes growth factor-induced ERK/MAPK activation. This PAR3-ERK/MAPK pathway further regulates actin organization and oriented cell division, both essential for BC elongation and hepatocyte maturation throughout liver development and regeneration. These findings provide new insights into a fundamental mechanism integrating cell proliferation, maturation, and architectural assembly, with implications for regenerative medicine and liver disease therapies.
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Project description:The complexity of transcriptome in human liver has not been clarified quite clearly so far. Here we collect various types of liver samples, including primary tumor, relapse tumor, benign adjacent, normal liver and tumor cell lines.High-throughput RNA sequecing data was generated for each sample.We assembled transcripts from these data under the guidance of GENCODE transcript annotation (v22).After the assembly, 94,272 genes and 371,388 transcripts were identified. Furthermore, we identified alternative splicing events from these genes and transcripts.
2020-06-01 | GSE101432 | GEO