Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential gene expression in the stellate ganglia of 16 week wistar and spontaneously hypertensive rat samples

ABSTRACT: Differential gene expression in the stellate ganglia of 16 week wistar and spontaneously hypertensive rat samples

PROVIDER: PRJNA433115 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6676310_1.fastq.gz	Fastqsanger.gz
	SRR6676310_2.fastq.gz	Fastqsanger.gz
	SRR6676311_1.fastq.gz	Fastqsanger.gz
	SRR6676311_2.fastq.gz	Fastqsanger.gz
	SRR6676312_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 32

Similar Datasets

Differential gene expression in the stellate ganglia of 16 week wistar and spontaneously hypertensive rat samples

Project description:Hypertension remains a poorly understood condition, and the understanding of the sympathetic nervous systems role in this disease remains even more limited. In this study, RNA-sequencing is used to identify transcriptomal differences in the sympathetic stellate ganglia between the 16-week-old normotensive wistar strain and the spontaneously hypertensive rat strain.This dataset should allow for further molecular characterisation of hypertensive changes in a cardiac-innervating sympathetic ganglion.

2018-06-21 | GSE110197 | GEO

Single-cell sequencing of the Wistar and SHR stellate ganglia

Project description:We report 10x Genomics based single-cell sequencing of the dissociated Wistar and Spontaneously Hypertensive Rat (SHR) stellate ganglia at 5-6 weeks of age.

2020-10-01 | GSE144027 | GEO

Gene expression profiling of cultured cells from brainstem of spontaneously hypertensive and Wistar Kyoto rats

Project description:Hypertension is a multifactor disease that possibly involves alterations in gene expression in hypertensive relative to normotensive subjects that are largely unknown. In this study we used high-density oligoarrays to compare gene expression profiles in cultured neurons and glia from pons and medulla oblongata of newborn spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats, a widely documented animal model of hypertension. We found 358 genes differentially expressed between SHR and WKY brainstem cells that preferentially map to 24 metabolic/signaling pathways. Some of the pathways and regulated genes identified herein are obviously related to blood pressure regulation; however there are several genes differentially expressed in SHR not yet associated to hypertension or participating in blood pressure regulation. These constitute a rich resource for the identification and characterization of novel genes involved in hypertension development, or associated to phenotypical differences observed in SHR relative to WKI. In conclusion, this study describes for the first time the gene profiling pattern of brainstem cells from SHR and WKY rats, which opens up new possibilities and strategies of investigation and possible therapeutics to hypertension, as well as for the understanding of the brain contribution in this pathology. Keywords: Gene expression profiling of cultured cells from brainstem of spontaneously hypertensive and normotensive Wistar Kyoto rats

2008-12-31 | GSE10366 | GEO

Transcription profiling of rat adrenal glands from spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto animals

Project description:We measured gene expression in the adrenal glands of the Spontaneously Hypertensive Rat (SHR) and Wistar-Kyoto rat (WKY) using Affymetrix RG-U34A GeneChips. All rats were aged-matched at 4-weeks. The rats were obtained from the colonies at the Univeristy of California San Diego, La Jolla, CA.

2007-11-01 | E-GEOD-1675 | biostudies-arrayexpress

Excessive leukotriene B4 in nucleus tractus solitarii is pro-hypertensive in spontaneously hypertensive rats.

2013-03-01 | GSE8796 | GEO

Transcription profiling of rat kidney from spontaneously hypertensive rats vs. controls

Project description:Development of renal transcriptome in spontaneously hypertensive rats (SHR) as compared to normotensive wistar kyoto rats (WKY) from birth to old age.

2008-04-30 | E-MEXP-1550 | biostudies-arrayexpress

Quantitative TMT proteomics of brainstem in spontaneously hypertensive rats

Project description:The brainstem, the core of the central nervous system, plays a vital role in controlling arterial blood pressure and its elevation of hypertension subtypes, especially essential hypertension. Integrative metabolic and proteomic profiling was performed on the brainstem samples of 11-week-old spontaneously hypertensive rats (SHRs) and age-matched normotensive Wistar rats, using hydrophilic interaction liquid chromatography-quadrupole/time-of-flight mass spectrometry (HILIC-Q/TOFMS) and nano-liquid chromatography-high-resolution-mass spectrometry (nano-LC-high-resolution-MS) combined with quantitative tandem mass tags (TMT).

2020-09-24 | PXD021210 | Pride

MicroRNA expression in mandibles of Wistar and Spontaneously Hypertensive rats with periodontal disease

Project description:MicroRNA expression in mandibles of Wistar and Spontaneously Hypertensive rats with periodontal disease

| PRJNA1009863 | ENA

Excessive leukotriene B4 in nucleus tractus solitarii is pro-hypertensive in spontaneously hypertensive rats.

Project description:We have used Affymetrix microarray-driven gene profiling to comprehensively describe the expression of mRNAs in the nucleus tractus solitarii (NTS) in the adult male spontaneously hypertensive rat (SHR) as compared to its normotensive parental Wistar-Kyoto (WKY) strain. Keywords: Gene expression NTS was dissected from hypertensive (SHR) and normotensive (WKY) strains of rat. For each structure, 10 independent Affymetrix Genechip 230 2.0 experiments were performed (5 SHR, 5 WKY), with each chip representing an independent biological replication (n=5).

2013-03-01 | E-GEOD-8796 | biostudies-arrayexpress

Expression data from RVLM of Wistar-Kyoko (WKY) rats and spontaneously hypertensive rats (SHR)

Project description:Expression data from RVLM of Wistar-Kyoko (WKY) rats and spontaneously hypertensive rats (SHR)

| PRJNA800328 | ENA