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Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

ABSTRACT: Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

PROVIDER: PRJNA433521 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6690130.fastq.gz	Fastqsanger.gz
	SRR6691170.fastq.gz	Fastqsanger.gz
	SRR6691180.fastq.gz	Fastqsanger.gz
	SRR6690131.fastq.gz	Fastqsanger.gz
	SRR6691171.fastq.gz	Fastqsanger.gz

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Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

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Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication

Project description:Chromatin organisation is disrupted genome wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naïve histones and old modified histones. It remains unknown whether the landscape of histone post-translational modifications (PTMs) is copied during DNA replication or the epigenomeis perturbed. Here we develop Chromatin Occupancy after Replication, ChOR-seq, a technology that combines chromatin immunopreciptation of histone marks and purification of newly replicated DNA by streptavidin pull-down followed by next generation sequencing. We use this technology to address propagation of epigenetic states across cell division and reveal that accurate recycling of modified parental histones ensures that positional information of histone marks is faithfully reproduced on daughter strands and inherited to daughter cells.

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Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication II

Project description:Chromatin organisation is disrupted genome wide during DNA replication. On newly synthesized DNA, nucleosomes are assembled from new naïve histones and old modified histones. It remains unknown whether the landscape of histone post-translational modifications (PTMs) is copied during DNA replication or the epigenomeis perturbed. Here we develop Chromatin Occupancy after Replication, ChOR-seq, a technology that combines chromatin immunopreciptation of histone marks and purification of newly replicated DNA by streptavidin pull down followed by next generation sequencing. We use this technology to address propagation of epigenetic states across cell division and reveal that accurate recycling of modified parental histones ensures that positional information of histone marks is faithfully reproduced on daughter strands and inherited to daughter cells.

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Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication III

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Recycling of parental histones preserves the epigenetic landscape during embryonic development (CUTAC)

Project description:Epigenetic inheritance during DNA replication requires an orchestrated assembly of nucleosomes from parental and newly synthesized histones. We analyzed Drosophila HisC mutant embryos harboring a deletion of all canonical histone genes, in which nucleosome assembly relies on parental histones from cell cycle 14 onwards. Lack of new histone synthesis and parental histone recycling leads to more accessible chromatin and reduced nucleosome occupancy. This leads to upregulated and spurious transcription, whereas the control of the developmental transcriptional program is partially maintained. Importantly, the genomic positions of modified parental H2A, H2B, and H3 are restored during DNA replication. Therefore, the results suggest that parental histones with active or repressive marks are recycled to preserve the epigenetic landscape during DNA replication in vivo.

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Recycling of parental histones preserves the epigenetic landscape during embryonic development (CUT&Tag)

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