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Transcriptome profiling of normal and transformed mouse urothelial cells

ABSTRACT: Transcriptome profiling of normal and transformed mouse urothelial cells

PROVIDER: PRJNA434288 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6737210.fastq.gz	Fastqsanger.gz
	SRR6737220.fastq.gz	Fastqsanger.gz
	SRR6737211.fastq.gz	Fastqsanger.gz
	SRR6737221.fastq.gz	Fastqsanger.gz
	SRR6737212.fastq.gz	Fastqsanger.gz

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Transcriptome profiling of normal and transformed mouse urothelial cells

Project description:Transcriptome analysis of urothelial KRT5-traced and KRT8-traced YFP-sorted cells with and without combinatorial loss of Trp53 and Pten. Bladders from 2-month-old KRT5-CreERT2, Rosa26YFP/LacZ mice, 2-month-old KRT8-CreERT2, Rosa26YFP/LacZ mice, 5-month-old KRT5-CreERT2, p53flox/flox, Ptenflox/flox, Rosa26YFP/+ mice, and 5-month-old KRT8-CreERT2, p53flox/flox, Ptenflox/flox, Rosa26YFP/+ mice were enzymatically dissociated, sorted for YFP by FACS, harvested, resuspended in Trizol and snap frozen for subsequent molecular analysis.

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Single-cell profiling identifies rare normal mesenchymal-like urothelial cells associated with sarcomatoid urothelial carcinoma

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