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Genome-wide maps of TBX1 state in transfected BCPAP cells

ABSTRACT: Genome-wide maps of TBX1 state in transfected BCPAP cells

PROVIDER: PRJNA435749 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6768630.fastq.gz	Fastqsanger.gz
	SRR6768629.fastq.gz	Fastqsanger.gz

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Genome-wide maps of TBX1 state in transfected BCPAP cells

Project description:Genome wide identification of TBX1 sites of occupancy in thyroid cancer cell line BCPAP cells by comparing control BCPAP cells transfected with pcDNA3.1-Vector (cotains Myc tag) with cells transfected with pcDNA3.1-TBX1 (contains Myc tag). By obtaining over 30 Million bases of sequence from chromatin immunoprecipitated DNA, we generated genome-wide chromatin-state maps of TBX1 transfected. We find that transcription factor TBX1 exerts tumor suppressive properties through regulating multiple downstream targets involved in PI3K/Akt and MAPK/Erk signaling pathways.

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