Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-Seq of CD8+ T cells during LCMV infection [WT infection]

ABSTRACT: RNA-Seq of CD8+ T cells during LCMV infection [WT infection]

PROVIDER: PRJNA436006 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6784360_1.fastq.gz	Fastqsanger.gz
	SRR6784360_2.fastq.gz	Fastqsanger.gz
	SRR6784370_1.fastq.gz	Fastqsanger.gz
	SRR6784370_2.fastq.gz	Fastqsanger.gz
	SRR6784380_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

Whole mouse genome analysis of LCMV-specific CD4 and CD8 T cells throughout acute and chronic LCMV infection.

Project description:CD4 and CD8 T cells display functional defects during chronic infection such as loss of certain cytokines. Recent studies have suggested that CD4 T cells may actually gain other functions, however. Here, we analyzed gene expression profiles from LCMV-specific CD4 and CD8 T cells throughout the response to either acute LCMV or chronic LCMV infection. This alllowed us to identify CD4-specific changes during chronic infection compared to acute infection but also revealed shared core regulators between CD4 and CD8 T cells. LCMV-specific CD4 and CD8 T cells were isolated 6, 8, 15 and 30 days post infection with LCMV Armstrong or LCMV clone 13. Naïve CD4 and CD8 T cells were also isolated from naïve mice as comparisons. Four replicates of each sample were hybridized. The only exception is LCMV-specific CD4 T cells isolated 6 days post infection with LCMV-Arm where only three replicates were hybridized.

2012-12-12 | E-GEOD-30431 | biostudies-arrayexpress

Primary and secondary CD8 T cells during acute and chronic LCMV infection

Project description:Understanding the response of memory CD8 T cells to persistent antigen re-stimulation and the role of CD4 T cell help is critical to the design of successful vaccines for chronic diseases. However, studies comparing the protective abilities and qualities of memory and naïve cells have been mostly performed in acute infections, and little is known about their roles during chronic infections. Herein, we show that memory cells dominate over naïve cells and are protective when present in large enough numbers to quickly reduce infection. In contrast, when infection is not rapidly reduced, memory cells are quickly lost, unlike naïve cells. This loss of memory cells is due to (i) an early block in cell proliferation, (ii) selective regulation by the inhibitory receptor 2B4, and (iii) increased reliance on CD4 T cell help. These findings have important implications towards the design of T cell vaccines against chronic infections and tumors. 16 samples are analyzed: 3 replicates of secondary effector CD8 P14 T cells at day 8 post-acute lymphocytic choriomeningitis virus (LCMV) infection; 4 replicates of secondary effector CD8 P14 T cells at day 8 post-chronic LCMV infection; 4 replicates of primary effector CD8 P14 T cells at day 8 post-acute LCMV infection; and 5 replicates of primary effector CD8 P14 T cells at day 8 post-chronic LCMV infection.

2011-08-22 | E-GEOD-30962 | biostudies-arrayexpress

P14 CD8 T cells during acute LCMV infection

Project description:P14 CD8 T cells during acute LCMV infection

| PRJNA632045 | ENA

Whole mouse genome analysis of LCMV-specific CD4 and CD8 T cells throughout acute and chronic LCMV infection.

2012-12-12 | GSE30431 | GEO

RNA-seq of P14 CD8 T cells during acute LCMV infection

Project description:We performed RNA-seq, ATAC-seq, and H3K27Ac ChIP-seq on P14 CD8 T cells during acute infection with LCMV Armstrong on days 0 (naïve cells), 9 (memory precursor effector cells (MPEC) and short-lived effector cells (SLECs)), and 40+ (memory cells) post infection.

2021-04-02 | GSE150441 | GEO

ATAC-seq of P14 CD8 T cells during acute LCMV infection

2021-04-02 | GSE150438 | GEO

H3K27Ac ChIP-seq of P14 CD8 T cells during acute LCMV infection

2021-04-02 | GSE150440 | GEO

ATAC-Seq of CD8+ T cell subsets during LCMV infection

Project description:ATAC-Seq of CD8+ T cell subsets during LCMV infection

| PRJNA419917 | ENA

RNA-Seq of CD8+ T cell subsets during LCMV infection

Project description:RNA-Seq of CD8+ T cell subsets during LCMV infection

| PRJNA419547 | ENA

Microarray analysis of CD8+ T cell subsets during LCMV infection