Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Expression data from ependymal cell cultures treated with MLN4924.

ABSTRACT: Expression data from ependymal cell cultures treated with MLN4924.

PROVIDER: PRJNA436123 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Expression data from ependymal cell cultures treated with MLN4924.

Project description:We identified that Foxj1 is degraded by the ubiquitin proteasome system. Foxj1 protein is stabilized by the cullin-RING ligase inhibitor MLN4924. We evaluated global changes to ependymal cell culture gene expression profiles during MLN4924 treatment.

2018-02-28 | GSE111182 | GEO

Expression data from ependymal cell cultures treated with EGF

Project description:Expression data from ependymal cell cultures treated with EGF

| PRJNA512281 | ENA

Expression data from ependymal cell cultures treated with EGF

Project description:We identified that EGF blocks differentiation of radial glial progenitors into multiciliated cells. We evaluated global changes to ependymal cell culture gene expression profiles during EGF treatment during differentiation.

2019-05-01 | GSE124518 | GEO

MLN4924 in chronic lymphocytic leukemia

Project description:CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug. CLL cells were treated with 1 microM MLN4924 or vehicle control for 24 hours. Cells were collected by centrifugation and B-cell were purified using negative selection (B cell purification Kit, Multenyi Biotech). RNA was isolated and submitted for Gene expression analysis

2013-03-05 | E-GEOD-44864 | biostudies-arrayexpress

RNA-seq of macrophages treated with or without MLN4924

Project description:MLN4924, a neddylation inhibitor with potential in cancer treatment, has anti - inflammatory effects. As atherosclerosis is an inflammatory disease related to autophagy and cell senescence, this study explored MLN4924's role in it. Focusing on foam cell formation, a key step in atherosclerosis, results showed MLN4924 downregulated scavenger receptors like CD36, and upregulated cholesterol efflux gene ABCA1. It also inhibited macrophage senescence and SASP - related factors, possibly via enhanced autophagy. Analyses revealed its impact on macrophage transcriptome and metabolism, with genes enriched in the PI3K - AKT pathway. MLN4924 inhibited AKT phosphorylation, regulated gene expression such as ABCA1, and modulated metabolite production. These suggest its potential as an anti - atherosclerotic agent for further research.

2025-11-18 | GSE292171 | GEO

MLN4924 in chronic lymphocytic leukemia

Project description:CLL cells obtained from patients with CLL were treated with MLN4924 to determine whether NFkB transcription targets were affected by the drug.

2013-03-05 | GSE44864 | GEO

RNA-seq of macrophages treated with or without MLN4924

Project description:RNA-seq of macrophages treated with or without MLN4924

| PRJNA1237321 | ENA

Gene expression data from ependymal tumor samples

Project description:Ependymal tumors across age groups have been classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patient outcome. We aimed at establishing a reliable molecular classification using DNA methylation fingerprints and gene expression data of the tumors on a large cohort of 500 tumors. Nine robust molecular subgroups, three in each anatomic compartment of the central nervous system (CNS), were identified. Total RNA from 209 ependymal tumor samples were hybridised to the Affymetrix HG U133 Plus 2.0 microarrays.

2015-05-21 | E-GEOD-64415 | biostudies-arrayexpress

Expression data of A375 melanoma cells after DMSO or MLN4924 treatment from 1 hour to 24 hour

Project description:Microarrays were used to determine the change in gene expression of genes involved in the CDT1/NAE pathway A375 cells were grown and then incubated in the presence of either DMSO as control or 650nM MLN4924. Cells were treated for 1, 2, 4, 8, and 24 hours. RNA extraction and hybridization on Affymetrix HG-U133Plus 2.0 arrays were performed.

2011-07-09 | E-GEOD-30531 | biostudies-arrayexpress

Expression data from Low Temperature Plasma-treated primary prostate cultures

Project description:Expression data from Low Temperature Plasma-treated primary prostate cultures

| PRJNA487945 | ENA