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Neural Lineage Progression Controlled by a Temporal Proliferation Program along the Apical-basial Axis

ABSTRACT: Neural Lineage Progression Controlled by a Temporal Proliferation Program along the Apical-basial Axis

PROVIDER: PRJNA437148 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6811570_1.fastq.gz	Fastqsanger.gz
	SRR6811570_2.fastq.gz	Fastqsanger.gz
	SRR6811571_1.fastq.gz	Fastqsanger.gz
	SRR6811571_2.fastq.gz	Fastqsanger.gz
	SRR6811572_1.fastq.gz	Fastqsanger.gz

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Neural Lineage Progression Controlled by a Temporal Proliferation Program along the Apical-basial Axis

Project description:This project is focused on understanding how the early driver factors act along the A-P axis. We have recently found that neural stem cells in the brain divide for longer, and bud off daughters that divide more, hence generating larger lineages that those found in the nerve cord. Intriguingly, the early factors are expressed at a higher level in the brain, and her functional studies indicate that this provides a driving input that contributes to the generation of the large brain lineages.

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Neural Lineage Progression Controlled by a Temporal Proliferation Program

Project description:Great progress has been made in identifying transcriptional programs that establish stem cell identity. In contrast, we have limited insight into how these programs are down-graded in a timely manner to halt proliferation and allow for cellular differentiation. Drosophila embryonic neuroblasts undergo such a temporal progression, initially dividing to bud off daughters that divide once (type I), then switching to generating non-dividing daughters (type 0), and finally exiting the cell cycle. We identify six early transcription factors that drive neuroblast and type I daughter proliferation. Early factors are gradually replaced by three late factors, acting to trigger the type I->0 daughter proliferation switch and eventually to stop neuroblasts. Early and late factors regulate each other and four key cell cycle genes, providing a logical genetic pathway for these transitions. The identification of this extensive driver-stopper temporal program controlling neuroblast lineage progression may have implications for studies in many other systems.

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Gene expression profiles along the tonotopic axis of the mouse cochlea during neonatal development

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Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

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