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Mast cell cytonemes as a defense mechanism against Coxiella burnetii

ABSTRACT: Mast cell cytonemes as a defense mechanism against Coxiella burnetii

PROVIDER: PRJNA438704 | ENA |

REPOSITORIES: ENA

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Mast cell cytonemes as a defense mechanism against Coxiella burnetii

Project description:Mast cells (MCs) are critical mediators of inflammation; however, their microbicidal activity against invading pathogens remains largely unknown. Here, we describe a nonpreviously reported antibacterial mechanism used by MCs against Coxiella burnetii, the agent of Q fever. We show that C. burnetii interaction with MCs does not result in bacterial uptake but rather induces the formation of extracellular actin filaments named cytonemes. MC cytonemes express cathelicidin and neutrophil elastase and mediate the capture and destruction of entrapped bacteria. We provide evidence that MC cytoneme formation and microbicidal activity are dependent on the cooperation of the scavenger receptor CD36 and Toll-like receptor 4. Taken together, our results suggest that MCs use an extracellular sophisticated mechanism of defense to eliminate intracellular pathogens, such as C. burnetii, before their entry into host cells.

2019-03-13 | GSE111971 | GEO

Early response of Coxiella burnetii to temperature stress

2011-01-01 | GSE21778 | GEO

Genotyping of Coxiella burnetii strains collection

Project description:Genotyping based on genomic comparative hybridization of different isolates of coxiella burnetii compared to NMI reference strain

2011-12-31 | GSE31543 | GEO

Multivalent vaccines demonstrate immunogenicity and protect against Coxiella burnetii aerosol challenge

Project description:C57BL/6 mice were immunized with Coxiella burnetii vaccine Q-VAX (Seqirus) and monitored for up to 83 days post immunization. Two different routes of immunization were observed - subcutaneous and intramuscular. Subcutaneously immunized animals were boosted on day 67.

2023-04-11 | GSE229293 | GEO

Mast Cell Cytonemes as a Defense Mechanism against Coxiella burnetii.

Project description: Not available

| S-EPMC6469977 | biostudies-literature

Human THP-1 Cells: Uninfected vs. Coxiella burnetii NMII infected compared to Uninfected with Chloramphenicol vs. Coxiella burnetii NMII infected with Chloramphenicol

Project description:A comparison was made between the THP-1(Human monocytic leukemia cells - TIB-202; ATCC) transcriptional responses of; (i) uninfected versus Coxiella burnetii NMII infected and (ii) uninfected versus Coxiella burnetii NMII infected THP-1 cells transiently treated with bacteriostatic levels (10μg/ml) of chloramphenicol (CAM). Briefly, infections were initiated and cultured in parallel with uninfected cells. At 48 hours post infection (hpi), media containing CAM (10μg/ml) was added to one set of cells (uninfected and infected THP-1 cells) and culturing was continued. The other set of cells were mock treated with normal media. Total RNA was isolated at 72 hpi from all conditions. Microarrays were performed for both condition sets and the results from each of the two microarrays were compared to define the host genes modulated by de novo C. burnetii NMII protein synthesis.

2010-10-01 | GSE23665 | GEO

Coxiella burnetii, the agent of Q fever, persists in adipocytes

Project description:Coxiella burnetii, the agent of Q fever, persists in humans despite specific immune responses: however, its reservoir remains unknown. We detected C. burnetii in adipose tissue from BALB/c and C57/BL6 mice 4 months after infection when no bacteria were found in other tissues. C. burnetii infected cultivated adipocytes, replicated within late phagosomes and induced a transcriptional program that was enriched for the expression of genes associated with inflammatory response, hormonal responses and cytoskeleton.

2014-05-25 | GSE46335 | GEO

Early response of Coxiella burnetii to temperature stress

Project description:Transcriptional profiling of Coxiella burnetii phase I (RSA 493) submitting either to Cold and Heat shock comparing to control untreated Coxiella burnetii phase I (RSA 493) grown at 35Â°C. Four experiments : Cold shock 30 min Vs 35Â°C; Cold shock 60 min Vs 35Â°C; Heat shock 30 min Vs 35Â°C; Heat shock 60 min Vs 35Â°C 3 biological replicates, independently grown and harvested. Four replicate per array.

2011-01-01 | E-GEOD-21778 | biostudies-arrayexpress

Coxiella burnetii CBU2016 Proteomics

Project description:Proteomic analysis of Coxiella burnetii to understand the function of CBU2016

2024-10-17 | PXD047783 | Pride

Genotyping of Coxiella burnetii strains collection

Project description:Genotyping based on genomic comparative hybridization of different isolates of coxiella burnetii compared to NMI reference strain Two-condition experiment, NMI vs. isolates. One replicate per isolate.

2011-12-31 | E-GEOD-31543 | biostudies-arrayexpress

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