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Drosophila melanogaster strain:wMel Wolbachia AND Wolbachia-free

ABSTRACT: Drosophila melanogaster strain:wMel Wolbachia AND Wolbachia-free Raw sequence reads

PROVIDER: PRJNA438737 | ENA |

REPOSITORIES: ENA

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Wolbachia endosymbiont of Drosophila melanogaster strain:wMel

Project description:Wolbachia endosymbiont of Drosophila melanogaster strain:wMel Genome sequencing

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Wolbachia endosymbiont of Drosophila melanogaster strain:wMel

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Metabolic analysis of wound response in Wolbachia infected Drosophila melanogaster

Project description:<p>Viral studies of Drosophila melanogaster typically involve virus injection with a small needle, causing post-injury a wounding/wound healing response, in addition to the effects of viral infection. However, the metabolic response to the needle injury is understudied, and many viral investigations neglect potential effects of this response. Furthermore, the wMel strain of the endosymbiont bacterium Wolbachia pipientis provides anti-viral protection in Drosophila. Here we used NMR-based metabolomics to characterise the acute wounding response in Drosophila and the relationship between wound healing and the Wolbachia strain wMel. The most notable response to wounding was found on the initial day of injury and lessened with time in both uninfected and Wolbachia infected flies. Metabolic changes in injured flies revealed evidence of inflammation, Warburg-like metabolism and the melanisation immune response as a response to wounding. In addition, at five days post injury Wolbachia infected injured flies were metabolically more similar to the uninjured flies than uninfected injured flies were at the same time point, indicating a positive interaction between Wolbachia infection and wound healing. This study is the first metabolomic characterisation of the wound response in Drosophila and its findings are crucial to the metabolic interpretation of viral experiments in Drosophila in both past and future studies.</p>

2025-11-18 | MTBLS13248 | MetaboLights

Wolbachia mCGH of Five Supergroup A Strains

Project description:Using microarray-based comparative genome hybridizations (mCGH), the genomic content of Wolbachia pipientis wMel from Drosophila melanogaster was compared to the Wolbachia from D. innubila (wInn), D. santomea (wSan), and three strains from D. simulans (wAu, wRi, wSim).

2009-05-11 | GSE13825 | GEO

Effect of Wolbachia (wMel strain) on gene expression in Dirofilaria immitis infected-Aedes aegypti

Project description:Wolbachia pipientis is an intracellular symbiotic bacterium found in insects and arthropods. Wolbachia can decrease the vectorial capacity for various pathogens, such as the dengue virus, in Aedes aegypti. The purpose of this study was to determine the effect of Wolbachia (wMel strain) on the vectorial capacity of Ae. aegypti for Dirofilaria immitis. We analyzed gene expression patterns by RNA-seq in addition to the D. immitis infection phenotype in Ae. aegypti infected with and without wMel. Four Ae. aegypti strains, MGYP2.tet, MGYP2, Liverpol (LVP)-Obihiro (OB), and LVP-OB-wMel (OB-wMel) were analyzed for transcriptome comparison in Malpighian tubule at 2 days post infection. The correlation between Wolbachia infection, D. immitis infection phenotype and immune-related genes expression in Ae. aegypti was investigated.

2024-05-27 | GSE268280 | GEO

Drosophila the 3rd instar larvae testis: Control vs. Wolbachia-infected

Project description:Transcriptional profiling of Drosophila melanogaster larval testes with and without the wMel strain of Wolbachia and found that 296 genes had at least a 1.5 fold change [q-value (%)<5%] in transcript levels, with 167 genes up-regulated and 129 genes down-regulated when comparing Wolbachia-infected flies to uninfected ones. Differential expression of genes related to metabolism, immunity, reproduction and other functions were observed.

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Drosophila the 3rd instar larvae testis: Control vs. Wolbachia-infected

2012-06-30 | E-GEOD-32601 | biostudies-arrayexpress

Drosophila melanogaster and Wolbachia pipientis

Project description:Drosophila melanogaster ovary transcriptomes uninfected and infected with wMel Wolbachia

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Wolbachia endosymbiont of Drosophila melanogaster strain:wMel

Project description:Genome sequencing and assembly of Wolbachia wMel variants

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Wolbachia endosymbiont of Drosophila melanogaster strain:wMel

Project description:Selection of new over-proliferative Wolbachia wMel variants

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