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Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

ABSTRACT: Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

PROVIDER: PRJNA439298 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6871140.fastq.gz	Fastqsanger.gz
	SRR6871150.fastq.gz	Fastqsanger.gz
	SRR6871141.fastq.gz	Fastqsanger.gz
	SRR6871142.fastq.gz	Fastqsanger.gz
	SRR6871143.fastq.gz	Fastqsanger.gz

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Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

Project description:Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

| PRJNA439293 | ENA

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

Project description:Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

| PRJNA439297 | ENA

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vivo]

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of the entire tumor. Method: MMTV-ErbB2 or RAS/DNP53-driven tumor mRNA profiles were generated by RNA-Sequencing. Results: Cyclin D1 knock down in RAS-G12V or MMTV-ErbB2-driven tumors leads to expression change of genes involved in developmental processes, but no change in FAS or FASL levels.

2021-03-20 | GSE112106 | GEO

Procaspase 3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a cancer cell-specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of the entire tumor. Method: RAS/DNP53-driven tumor mRNA profiles were generated by RNA-Sequencing. Reads from RNA-Seq samples were mapped to the Mus musculus reference genome (MGSCv37) using Bowtie and TopHat. Transcript abundance and differential expression were called by Cufflinks. Results: Cyclin D1 knock down in RAS-G12V or MMTV-ErbB2-driven tumors leads to expression change of genes involved in developmental processes, but no significant change in apoptotic genes was recorded among the samples.

2020-04-11 | GSE63578 | GEO

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation [in vitro]

Project description:Purpose: To gain insights into the activity of Cyclin D1 in tumor maintenance, we developed a specific RNAi strategy to knock down its expression and analyze the outcome on gene expression profile of RAS/DNP53-driven cancer cells (transformed MEFs). Cells were treated by RNAi or with Leptomycin B over night. Method: RAS/DNP53-transformed MEFs mRNA profiles were generated by RNA-Sequencing. Results: Cyclin D1 knock down in RAS-G12V-driven cancer cells leads to expression change of genes involved in developmental processes, but no change in FAS or FASL levels.

2021-03-20 | GSE112105 | GEO

Sustained expression of cyclin D1 or cyclin D1/KE in mouse mammary gland

Project description:Analysis of mammary glands from tet-inducible(rtTA) transgenic mice expressing cyclin D1 using Affymetrix Mouse Gene 1.0 ST GeneChip arrays. MMTV-rtTA transgenic mice (MMTV-Mouse Mammary Tumor Virus promoter) were cross-mated to cyclin D1 transgenic mice under control of tet operon. 8-week-old tetracycline-inducible cyclin D1/rtTA bi-transgenic pregnant female mice (12 days postcoitus) were treated with doxycycline through drinking water supplementation at a final concentration of 2 mg/ml. Control mice were rtTA transgenics alone and treated in the same manner. After 7 days of doxycycline treatment, the mice were sacrificed and mammary glands taken for RNA isolation. Results provide insight into the in vivo gene expression pattern regulated by cyclin D1 through acute induction. Analysis of mammary glands from MMTV-cyclin D1/WT and MMTV-cyclin D1/KE using Affymetrix Mouse 430A v2.0 GeneChip arrays. Cyclin D1 point mutant, cyclin D1/KE K112E (K112E) contains a lysine to glutamine substitution at amino acid position 112. cyclin D1. The cyclin D1/KE mutant fails to induce cyclin D1-dependent kinase activity. Female MFD1, MFD1-KE, and WT mice were monitored twice weekly, up to 760 days, for the development of palpable tumors. Those developing palpable tumors were sacrificed within a week of tumor detection. Tumors were dissected and portions snap frozen for RNA isolation. Results provide insight into the in vivo gene expression pattern regulated by cyclin D1 that is kinase independent.

2013-12-31 | GSE43216 | GEO

Procaspase3-Cyclin D1 assembly rewires cancer cells from apoptosis to proliferation

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-20 | GSE112107 | GEO

Sustained expression of cyclin D1 or cyclin D1/KE in mouse mammary gland

2013-12-31 | E-GEOD-43216 | biostudies-arrayexpress

miR-193b represses cell proliferation and regulates cyclin D1 in melanoma

Project description:This SuperSeries is composed of the following subset Series: GSE18509: miR-193b represses cell proliferation and regulates cyclin D1 in melanoma: benign nevi and metastatic melanoma GSE18510: miR-193b represses cell proliferation and regulates cyclin D1 in melanoma: Malme-3M Refer to individual Series

2010-05-16 | E-GEOD-18512 | biostudies-arrayexpress

Expression data from JVM13 cells with cyclin D1 exogenous overexpression

Project description:Mantle cell lymphoma (MCL) is an aggressive B-cell neoplasm characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell cycle regulator and also has a role in transcription, but the effect of the latter in tumorigenesis remains largely unknown. Here, we investigated the transcriptional role of cyclin D1 in MCL and its impact on the pathogenesis of this neoplasm. Integrating genome-wide expression analysis of cyclin D1-silenced and overexpressing cells with cyclin D1 chromatin binding profiles, we identified a cyclin D1-activated transcriptional program in MCL cells. We used microarrays to analyze the genome-wide expression modulation in cyclin D1 overexpression models established in the cyclin D1-negative lymphoblastoid cell line JVM13.

2021-06-30 | GSE144095 | GEO

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