Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Characterizing the cases of HFMD using RNA-seq

PROVIDER: PRJNA448488 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR6928690_1.fastq.gz	Fastqsanger.gz
	SRR6928690_2.fastq.gz	Fastqsanger.gz
	SRR6928700_1.fastq.gz	Fastqsanger.gz
	SRR6928700_2.fastq.gz	Fastqsanger.gz
	SRR6928691_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

E-GEOD-63776

Project description:Altering cancer transcriptomes using epigenomic inhibitors [RNA-Seq]

2025-01-24 | E-GEOD-63776 | ExpressionAtlas

Project description:Characterizing the cases of patients with respiratory diseases using RNA-seq

| PRJNA540900 | ENA

E-GEOD-41745

Project description:Transcriptional Profiling of Psoriasis Using RNA-seq Reveals Previously Unidentified Differentially Expressed genes

2025-01-24 | E-GEOD-41745 | ExpressionAtlas

E-GEOD-22260

Project description:Comparative transcriptomic analysis of prostate cancer and matched normal tissue using RNA-seq

2025-01-24 | E-GEOD-22260 | ExpressionAtlas

E-GEOD-114103

Project description:Transciptomic profiling of the uterii of laying and non-laying hens using RNA-seq

2020-10-20 | E-GEOD-114103 | ExpressionAtlas

E-MTAB-8067

Project description:RNA-seq of CK2alpha-silenced H9-c2 derived myoblasts using siRNA or doxycyclin inducible shRNA.

2019-08-30 | E-MTAB-8067 | ExpressionAtlas

E-MTAB-8631

Project description:Functional validation of a gene regulatory element as a candidate cancer driver using RNA-seq in HEK293 cells

2025-01-16 | E-MTAB-8631 | ExpressionAtlas

E-MTAB-8008

Project description:Transcriptome analysis of human brain microvascular endothelial cells response to Neisseria meningitidis and its antigen MafA using RNA-seq

2025-01-23 | E-MTAB-8008 | ExpressionAtlas

Pathogenicity and landscape of differential gene expression in mice orally infected with clinical coxsackievirus A6 (CA6)

Project description:Hand, foot, and mouth disease (HFMD) is caused by more than 20 pathogenic enteroviruses belonging to the Picornaviridae family and Enterovirus genus. Since the introduction of the EV71 vaccine in 2016, the number of HFMD cases caused by EV71 has decreased. However, cases of infections caused by other enteroviruses, such as coxsackievirus A6 (CA6) and CA10, have been increasing accordingly. In this study, we used a clinical isolate of CA6 to establish an intragastric infection mouse model using 7-day-old mice to mimic the natural transmission route, by which we investigated the differential gene expression profiles associated with virus infection and pathogenicity. After intragastric infection, mice exhibited hind limb paralysis symptoms and weight loss, similar to those reported for EV71 infection in mice. The skeletal muscle was identified as the main site of virus replication, with a peak viral load reaching 2.31 × 107 copies/mg at 5 dpi and increased infiltration of inflammatory cells. RNA sequencing analysis identified differentially expressed genes (DEGs) after CA6 infection. DEGs in the blood, muscle, brain, spleen, and thymus were predominantly enriched in immune system responses, including pathways such as Toll-like receptor signalling and PI3K-Akt signalling. Our study has unveiled the genes involved in the host immune response during CA6 infection, thereby enhancing our comprehension of the pathological mechanism of HFMD.

2024-01-10 | GSE243200 | GEO

E-MTAB-8054

Project description:Transcriptome analysis of human brain microvascular endothelial cells response to Streptococcus pneumoniae and its antigen Adhesion lipoprotein using RNA-seq

2025-01-16 | E-MTAB-8054 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data