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The effect of circadian rhythm on gene expression in human skin

ABSTRACT: The effect of circadian rhythm on gene expression in human skin

PROVIDER: PRJNA448675 | ENA |

REPOSITORIES: ENA

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The effect of circadian rhythm on gene expression in human skin.

Project description:The effect of circadian rhythm on gene expression in human skin.

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Investigating the effects of circadian rhythm on the human skin lipidome

Project description:<p>The circadian rhythm is a 24 h cycle that harmonises the activity of organs – including the skin – to a daily routine using neurological and hormonal signals. Limited research has been done to understand the effects of the circadian rhythm on the skin lipidome. We used reversed-phase liquid chromatography-mass spectrometry (RPLC-MS) in a longitudinal study to investigate temporal changes to the skin lipidome over a 24 h cycle for eight healthy participants. All statistical analyses were performed with a group-mean and individual-mean data approach. Using cosinor analysis p-values, a total of 29 metabolites (0.67% of all detected metabolites) exhibited a statistically significant circadian rhythmicity across participants; however, individually, a range of 3.51–18.53% of metabolites were considered rhythmic. The use of FDR q-values and Lomb–Scargle analysis showed no circadian metabolites. Using PCA and PLS-DA, no significant clustering based on timepoints was observed across participants; however, half of individuals showed significant metabolite clustering at 07:30. Further, sebum-specific squalene and sapienic acid as well as stratum corneum-specific cholesterol sulfate showed no significant differences in concentrations across timepoints. While individuals exhibited temporal differences, as an averaged healthy cohort the impacts by the circadian rhythm or time of sampling were considered negligible.</p>

2025-10-17 | MTBLS12607 | MetaboLights

The effect of circadian rhythm on gene expression in human skin II

Project description:The effect of circadian rhythm on gene expression in human skin II

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The effect of circadian rhythm on gene expression in human skin III

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Effect of d-alanine on circadian rhythm

Project description:To investigate the effect of d-ala on circadian rhythm.

2023-12-28 | GSE227755 | GEO

The effect of circadian rhythm on gene expression in human skin

Project description:Skin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. Like other tissues, skin is subject to temporal fluctuations in physiological responses under both homeostatic and stressed states. To gain insight into these fluctuations, we investigated the role of the circadian clock in the transcriptional regulation of human epidermal samples collected in a time-ordered fashion. We also determined whether this circadian patterning could be applied to unordered (i.e., randomly collected) human epidermal samples. The purpose of this study was to gain insight into the evolutionarily-conserved rhythmic patterns of the circadian transcriptome in human skin and how it relates to published transcriptomes from other human tissues.

2018-11-13 | GSE112660 | GEO

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Project description:Skin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. Like other tissues, skin is subject to temporal fluctuations in physiological responses under both homeostatic and stressed states. To gain insight into these fluctuations, we investigated the role of the circadian clock in the transcriptional regulation of skin The purpose of this study was to gain insight into the evolutionarily-conserved rhythmic patterns of the circadian transcriptome in human skin and how it relates to published transcriptomes from other human tissues.

2020-07-20 | GSE139300 | GEO

The effect of circadian rhythm on gene expression in human skin III

Project description:Skin is the largest organ in the body and serves important barrier, regulatory, and sensory functions. Like other tissues, skin is subject to temporal fluctuations in physiological responses under both homeostatic and stressed states. To gain insight into these fluctuations, we investigated the role of the circadian clock in the transcriptional regulation of skin The purpose of this study was to gain insight into the evolutionarily-conserved rhythmic patterns of the circadian transcriptome in human skin and how it relates to published transcriptomes from other human tissues.

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Circadian rhythm in NIH3T3 cells

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2015-12-31 | GSE66243 | GEO

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