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Pro-viral miRNAs are detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS

ABSTRACT: Pro-viral miRNAs are detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS

PROVIDER: PRJNA448844 | ENA |

REPOSITORIES: ENA

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Pro-viral miRNAs are detected in BALF extracellular vesicles of patients with influenza virus-induced ARDS

Project description:Influenza A virus (IAV) causes severe respiratory infections and alveolar epithelial damage resulting in acute respiratory distress syndrome (ARDS). Extracellular vesicles (EV) have been shown to mediate cellular crosstalk in inflammation by transfer of microRNAs. In this study, we found significant changes in the miRNA composition of EVs in the broncho-alveolar lavage fluid (BALF) from patients with IAV-induced ARDS. Among the nine significantly deregulated microRNAs, miR-17-5p was upregulated in patients` BALF and in EVs of IAV-infected lung epithelial cells (A549). In these cells, transfer of miR-17-5p strongly downregulated expression of the antiviral factor Mx1 and significantly enhanced IAV replication.

2019-04-01 | GSE112728 | GEO

Pathophysiological changes in plasma and BALF of patients with ARDS based on proteomics

Project description:Acute Respiratory Distress Syndrome (ARDS) remains a significant clinical challenge, with its pathogenesis not fully understood. Proteomic analyses of plasma and bronchoalveolar lavage fluid (BALF) in patients with ARDS have been performed to uncover diagnostic and prognostic markers, although previous studies have not adequately focused on longitudinal biomarker comparison. This study aims to elucidate the proteomic profiles of patients with ARDS in acute and subacute phases to better understand pathophysiological progression of ARDS.

2025-05-26 | PXD055757 | Pride

CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia

Project description:To screen and validate abnormally expressed circRNAs in exosomes from BALF of patients with ARDS caused by severe pneumonia, and then evaluate the diagnostic values of these circRNA for ARDS

2022-11-11 | GSE217763 | GEO

microRNA sequencing of MSC-derived Extracellular vesicles

Project description:Human bone marrow-derived MSCs were stimulated with Bronchoalveolar lavage fluid (BALF) from healthy individuals or patients with ARDS, Cystic Fibrosis, Cystic Fibrosis positive for Aspergillus or untreated untreated MSC. Extracellular vesicles were isolated from MSC conditioned medium following minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles (J Extracell Vesicles. 2014 Dec 22:3:26913. doi: 10.3402/jev.v3.26913. eCollection 2014). In Phase 1 of this study, differential expression as well as discriminant analysis was used to identify 14 microRNAs that were differentially expressed in MSC-derived EVs from MSCs exposed to BALF from ARDS patients compared to healthy controls. The effect of EVs on cellular physiology and was demonstrated in vitro by demonstration that wwo miRNAs involved in regulation of the cystic fibrosis transmembrane conductance regulator (CFTR), miRNA-145-5p and miRNA-138-5p, were also significantly increased in ARDS BALF-exposed hMSCs EVs. Functionally, EVs from hMSCs exposed to either ARDS or HV BALF had differential on CFTR Cl- secretion by cultured primary human bronchial epithelial cells, an effect predicted to reduce mucociliary clearance.

2025-03-12 | GSE282919 | GEO

BALF single-cell landscape in CARDS and non-ARDS patients at two time points

Project description:BALF single-cell landscape in CARDS and non-ARDS patients at two time points

| PRJNA1004268 | ENA

BALF single-cell landscape in CARDS and non-ARDS patients at two time points

Project description:In this study, single-cell sequencing of the BALF of CARDS patients yielded the following results: (1) IL1B+ neutrophils were significantly increased in the BALF of CARDS patients with exacerbated disease, which was associated with poor prognosis of CARDS patients, and this type of neutrophils underwent fatty acid metabolism reprogramming in comparison with other types of neutrophils, which may be related to their high-inflammatory response. (2) IL1B+ neutrophils promoted TNF secretion from hyperinflammatory type M1 macrophages through a caspase-dependent pathway, suggesting that neutrophil-macrophage interactions play an important role in the mechanism of CARDS development.

2024-05-15 | GSE240580 | GEO

HIV BALF

Project description:HIV BALF

| PRJEB73333 | ENA

BALF Sample

Project description:BALF Sample Metagenome

| PRJNA1191228 | ENA

Scnn1b transgenic mice: BALF exosome proteomics

Project description:We detected BALF exosome-derived proteins from adult Scnn1b transgenic (Scnn1b-Tg+) and wild type (WT) mice. A total of 3144 and 3119 proteins were identified in BALF exosomes from Scnn1b-Tg+ and WT mice, respectively.

2024-08-09 | MSV000095568 | MassIVE

GNPS - Untargeted metabolomics of mice BALF (treatment of ARDS with EVs)

Project description:Bronchoalveolar lavage fluid (BALF) collected from mice with and without the induction of Acute Respiratory Distress Syndrome (ARDS) and treated with engineered extracellular vesicles (EVs). BALF extracts were analyzed by LC-MS/MS performed in an 6545 Q-TOF LC/MS (AGILENT) using a Poroshell 120 SB-C18 reversed phase column (2.1 x 100 mm, 2.7 um)

2022-06-24 | MSV000089725 | GNPS

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