Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression of nucleolin or TRA2B4-silencing HCT116 cells

ABSTRACT: Gene expression of nucleolin or TRA2B4-silencing HCT116 cells

PROVIDER: PRJNA448909 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression of nucleolin or TRA2B4-silencing HCT116 cells

Project description:TRA2β4 is transcribed from the human transformer 2β(TRA2B) gene and overexpressed in colon cancer cells. Nucleolin is one of RNA-binding proteins to regulate cell survival and proliferation. In this study, TRA2β4 and Nucleolin levels were reduced in colon cancer HCT116 cells and gene expression levels were measured using microarray analysis.

2018-04-06 | GSE112758 | GEO

Gene expression profiles of LMNA-V6 silencing or overexpression in HCT116 cells

Project description:Gene expression profiles of LMNA-V6 silencing or overexpression in HCT116 cells

| PRJNA714559 | ENA

Genome-wide analysis of gene expression regulated by nucleolin in mouse embryonic stem cells

Project description:To further explore the function and underlying mechanism of nucleolin in embryonic stem cells (ESCs), we compared the transcription profile of tetracycline (Tc)-inducible EGFP (as a control) or nucleolin siRNA expression-stable ESCs cultured with or without Tc for 3 days, and identified distinct classes of up- and down-regulated genes by nucleolin in mouse ESCs. Total RNA obtained from CGR8 ES cells stably integrated with Tc-inducible siRNA EGFP, nucleoin-1 or nucleolin-2 cultured with or without Tc for 3 days, and then hybridized to Illumina Sentrix Mouse-6 v2.0 BeadChips. Three replicates each condition.

2011-10-19 | E-GEOD-23993 | biostudies-arrayexpress

Genome-wide analysis of gene expression regulated by nucleolin in mouse embryonic stem cells

2011-10-20 | GSE23993 | GEO

Gene expression profiles of LMNA-V6 silencing or overexpression in HCT116 cells

Project description:Lamin A/C proteins, major components of the nuclear lamina, are encoded by the LMNA gene. These proteins have multiple cellular functions. LMNA has implications in cancer; however, its mechanisms of dysregulation in cancer cells are not yet fully understood. Among the LMNA transcript variants, we focused on a spliced variant 6 (termed LMNA-V6), which contains unique 3 exons upstream of exon 1 of LMNA. In this study, after LMNA-V6 levels were modulated by overexpression or silencing in colon cancer HCT116 cells, gene expression profiles were measured using microarray analysis.

2021-03-16 | GSE168912 | GEO

Effect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells

Project description:AS1411 is a G-rich DNA aptamer that targets the multifunctional RNA-binding protein nucleolin. AS1411 has both antiproliferative and cell size-regulating activities and has been evaluated for clinical utility, reaching phase II trials as an anticancer agent. The mechanisms underlying the different activities of AS1411 are not completely understood and broad characterization of its molecular effects is lacking. Here, we used a multi-omics approach to profile transcriptome, proteome and lipidome changes in AS1411-treated NIH-3T3 cells, which increase in size in response to the aptamer. We found that AS1411 caused downregulation of cholesterol biosynthesis pathway enzymes at both mRNA and protein levels, without an accompanying drop in cellular cholesterol levels. In addition, AS1411 induced changes in several lipid classes, including increases in phospatidylethanolamine levels. Thus, nucleolin regulates lipid biosynthesis and homeostasis, potentially underlying its roles in cell proliferation and size control.

2025-10-27 | GSE274745 | GEO

RIP-seq reveals the interactome of nucleolin in activated CD4+ T cells

Project description:During the actiation of CD4+T cells, the pri-miRNAs translocated from cytoplasma into nucleus.However, the mechanism remains unkown. We found that pri-miR-31 interact with nucleolin through G-guadruplex struction in pri-miR-31. We then transfected ASO to destribute the interaction of nucleolin and G4 struction. In order to identify the interacting RNA, including miRNA precuser and mRNA, we performed the RIP-seq Immunoprecipited by anti-nucleolin and IgG.

2025-04-11 | GSE263822 | GEO

Effect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells

Project description:Effect of nucleolin-binding aptamer AS1411 on gene expression in 3T3 cells

| PRJNA1147748 | ENA

Gene expression of 5-azacytidine-treated HCT116 cells

Project description:Gene expression of 5-azacytidine-treated HCT116 cells

| PRJNA472156 | ENA

Gene expression of human colon cancer HCT116 cells

Project description:Gene expression of human colon cancer HCT116 cells

| PRJNA512131 | ENA