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Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

ABSTRACT: Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

PROVIDER: PRJNA453153 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7059090.fastq.gz	Fastqsanger.gz
	SRR7059100.fastq.gz	Fastqsanger.gz
	SRR7059091.fastq.gz	Fastqsanger.gz
	SRR7059101.fastq.gz	Fastqsanger.gz
	SRR7059092.fastq.gz	Fastqsanger.gz

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Extensive Transcriptional and Translational Regulation Occur During the Maturation of Malaria Parasite Sporozoites

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Project description:Malaria is a mosquito-borne infectious disease of humans and other animals. It is caused by the parasitic protozoan, Plasmodium. Sporozoites, the infectious form of malaria parasites, are quiescent when they remain in the salivary glands of the Anopheles mosquito until transmission into a mammalian host. Metamorphosis of the dormant sporozoite to its active form in the liver stage requires transcriptional and translational regulations. Here, we summarize recent advances in the translational repression of gene expression in the malaria sporozoite. In sporozoites, many mRNAs that are required for liver stage development are translationally repressed. Phosphorylation of eukaryotic Initiation Factor 2α (eIF2α) leads to a global translational repression in sporozoites. The eIF2α kinase, known as Upregulated in Infectious Sporozoite 1 (UIS1), is dominant in the sporozoite. The eIF2α phosphatase, UIS2, is translationally repressed by the Pumilio protein Puf2. This translational repression is alleviated when sporozoites are delivered into the mammalian host.

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Addendum: Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites.

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