Project description:We used microarrays to detail the global gene expression in AGS gastric cancer cells overexpressing WTX, a tumor suppressor frequently inactivated in Wilms tumor. Results provide insight into roles for WTX in gastric cancer cells.
Project description:Comparing to matched normal mucosa, WTX was lost in most of human gastric cancers (Zhang et al., 2016). We analyzed the microRNA expression profiling among WTX low human colorectal cancer tissues and matched adjacent WTX high normal colorectal mucosa. The aimed to identify the unique signature of miRNAs which related to WTX loss in human colorectal cancers.
Project description:AVIL is an oncogenic driver of gastric cancer. To test the oncogenic ability of AVIL, we established stable AVIL overexpression in normal human gastric epithelial cell line GES1 and performed RNA-sequence. We also use AVIL inhibitor compound A to treat gastric cancer cell line AGS and do transcriptome analysis.