Project description:A protocol was established for the derivation of Schwann cell-like cells from human BMSCs. The commitment to the Schwann cell fate was acquired by Schwann cell-like cells in co-culture with rat DRG neurons. Microarray analysis provided evidence that the human BMSC-derived Schwann cells were functionally mature.
Project description:We investigated the transcriptomic alterations in human retinal microvascular pericytes (HRMVPC-Immortalized) exposed to normal and high glucose conditions, with or without co-culture with human retinal microvascular endothelial cells (HRMEC-Immortalized). The study aimed to elucidate how glucose levels and endothelial interaction influence pericyte gene expression, providing insights into the cellular mechanisms potentially involved in diabetic retinopathy.