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Prediabetes Induced by a Single Autoimmune B cell Clone

ABSTRACT: Prediabetes Induced by a Single Autoimmune B cell Clone

PROVIDER: PRJNA472780 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7208340.fastq.gz	Fastqsanger.gz
	SRR7208333.fastq.gz	Fastqsanger.gz
	SRR7208334.fastq.gz	Fastqsanger.gz
	SRR7208335.fastq.gz	Fastqsanger.gz
	SRR7208336.fastq.gz	Fastqsanger.gz

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Project description:While B cells play a significant role in the onset of type-1 diabetes (T1D), little is know about their role in those early stages. Thus, to gain new insights into the role of B cells in T1D, we converted a physiological early pancreas-infiltrating B cell into a novel BCR mouse model using Somatic Cell Nuclear Transfer (SCNT). Strikingly, SCNT-derived B1411 model displayed neither developmental block nor anergy. Instead, B1411 underwent spontaneous germinal center reactions. Without T cell help, B1411-Rag1-/- was capable of forming peri-/intra-pancreatic lymph nodes, and undergoing class-switching. RNA-Seq analysis identified 93 differentially expressed genes in B1411 compared to WT B cells, including Irf7, Usp18, and Mda5 that had been linked to a potential viral etiology of T1D. We also found various members of the oligoadenylate synthase (OAS) family to be enriched in B1411, such as Oas1, which had recently also been linked to T1D. Strikingly, when challenged with glucose B1411-Rag1-/- mice displayed impaired glucose tolerance.

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Prediabetes Induced by a Single Autoimmune B cell Clone

Project description:This SuperSeries is composed of the SubSeries listed below.

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Cardiac miRNA expression changes induced by prediabetes

Project description:The aim of the experiment was the analysis of key molecular changes with an unbiased, transcriptomics-based approach in a prediabetes model. Small RNA sequencing analysis was applied to explore the expression changes resulted high-fat chow (supplemented with 40% lard) diet for 21 weeks and a single low dose of streptozotocin (20 mg/kg) treatment at week 4. Long-Evans rats were used in the present study. Left ventricular samples(n=6) of both prediabetic and control groups were analyzed.

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Prediabetes Induced by a Single Autoimmune B cell Clone [RNA-seq]

Project description:SCNT-derived B cell model displays spontaneous germinal center reaction, infiltration of pancreas (in RAG1-/- background) and impaired glucose tolerance.

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Project description:SCNT-derived B cell model displays spontaneous germinal center reaction, infiltration of pancreas (in RAG1-/- background) and impaired glucose tolerance.

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Exercise training markedly augments dietary weight loss-induced improvements in multi-organ system metabolic function in people with obesity and prediabetes

Project description:The additional therapeutic effects of regular exercise during a dietary weight loss program in people with obesity and prediabetes are unclear. We evaluated the effect of 10% weight loss, induced within ~5 months by calorie-restriction alone (Diet-ONLY, n=8) or calorie-restriction plus multi-modal exercise training (Diet+EX, n=8), on metabolic function in people with obesity and prediabetes. Whole-body (primarily muscle) and hepatic insulin sensitivity were 2-3 fold greater in the Diet+EX than the Diet-ONLY group, and were accompanied by increased muscle expression of genes involved in mitochondrial biogenesis, energy metabolism and angiogenesis in the Diet+EX group without any change in the Diet-ONLY group. There were no differences between groups in plasma branched-chain amino acids or markers of inflammation, and both interventions caused similar changes in the gut microbiome. These results demonstrate that adding regular exercise to a diet-induced weight loss program has profound metabolic benefits in people with obesity and prediabetes.

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