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RNA-seq analysis of RPE cells from Sox9 cKO and wild-type control mice

ABSTRACT: RNA-seq analysis of RPE cells from Sox9 cKO and wild-type control mice

PROVIDER: PRJNA473157 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7221050.fastq.gz	Fastqsanger.gz
	SRR7221060.fastq.gz	Fastqsanger.gz
	SRR7221051.fastq.gz	Fastqsanger.gz
	SRR7221061.fastq.gz	Fastqsanger.gz
	SRR7221052.fastq.gz	Fastqsanger.gz

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RNA-seq analysis of RPE cells from Sox9 cKO and wild-type control mice

Project description:RNA-seq analysis was applied in triplicates to RPE cells extracted at two developmental time-points (E15.5 and P5) from Sox9-cKO and wild-type control mice

2018-07-17 | GSE114945 | GEO

ChIP-seq analysis of SOX9 in hES-RPE cells

Project description:SOX9 binding sites were profiled in RPE cells generated from human embryonic stem cells (hES-RPE)

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RNAseq of souble factors in RPE cells from Cryba1 conditional knockout (cKO) mice

Project description:The study was aimed at understanding the expression of known neutrophil regulating factors in the retinal pigment epithelium (RPE) cells with increasing age in a mouse model (Cryba1 cKO, mice lacking gene which codes for beta A3/A1-crystallin protein only in the RPE cells) of age-related macular degeneration

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Next Generation Sequencing of skin from wild-type and ADAM17 cKO (Sox9-Cre x ADAM17fl/fl) mice

Project description:Purpose: Transcriptomic analysis of ADAM17 cKO mice, a mouse model of atopic dermatitis. Methods: Skin was harvested from 10-week-old wild-type and ADAM17 cKO mice and were subjected to next generation sequencing as described. Results: Of 13,573 genes analyzed by GSA, 2514 differentially expressed genes (DEGs) were detected in ADAM17 cKO skin using a standard definition including both statistically significant change (P-value < 0.01; FDR < 0.05) and effect size (|fold change| > 2) . These DEGs included genes important in lipid metabolism and keratinization, consistent with the understanding of barrier dysfunction in atopic inflammation, as well as significant immunologic pathways in adaptive and innate immunity previously identified in the human AD transcriptome Conclusions: Our study reveals that the transcriptome of ADAM17 cKO mice capture a part of upregulated genes previously observed in human AD skin.

2018-05-01 | GSE107687 | GEO

Next Generation Sequencing of skin from wild-type and ADAM17 cKO (Sox9-Cre x ADAM17fl/fl) mice

Project description:Next Generation Sequencing of skin from wild-type and ADAM17 cKO (Sox9-Cre x ADAM17fl/fl) mice

| PRJNA421028 | ENA

ChIP-seq analysis of SOX9 in hES-RPE cells

Project description:ChIP-seq analysis of SOX9 in hES-RPE cells

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mouse retinal pigmented epithelium (RPE)-LC/MS/MS

Project description:In this experiment, we compared the phosphorylated protein profile of Cryba1 cKO (RPE-specific) RPE tissue and that of the age-matched control samples.

2021-09-07 | PXD026777 | Pride

Gene expression in mouse RPE in wild-type and MFRP mutants

Project description:We compared gene expression in retinal pigment epithelium (RPE) isolated from wild-type mice and two different membrane-type frizzled-related protein (Mfrp) mutants. The rd6 mutant is described in Hawes, et al. (2000) IOVS 41:3149-3157. The 174delG mutant is described in Fogerty, et al (2011) IOVS 52:7256-7266.

2019-07-01 | GSE116693 | GEO

Analysis of differential expression genes in the lung of Eif4b CKO mice and wild type mice

Project description:To identify important differential expression genes（mRNA） in the lung of Eif4b CKO mice and wild type mice with or without IAV infection, transcriptome RNA sequencing in the lungs of uninfected or infected eIF4B CKO mice and control mice was performed

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RNA-sequencing analysis of adult mouse wild type (Prdm16-Mx1-Cko/Cko +/+) and Prdm16-/- (Prdm16-Mx1-Cko/Cko Tg/+) Long Term-Hematopoietic Stem Cells (LT-HSC).

Project description:RNA-sequencing analysis of adult mouse wild type (Prdm16-Mx1-Cko/Cko +/+) and Prdm16-/- (Prdm16-Mx1-Cko/Cko Tg/+) Long Term-Hematopoietic Stem Cells (LT-HSC).

| PRJNA644817 | ENA

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