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Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

ABSTRACT: Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

PROVIDER: PRJNA475007 | ENA |

REPOSITORIES: ENA

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Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders

Project description:Maresin 1 administered to mice prior to orthopedic surgery exerts distinct anti-inflammatory and pro-resolving effects through regulation of MΦ infiltration, NF-κB signaling, and cytokine release. We used microarrays to detail the global programme of gene expression underlying Maresin 1 effect on mouse hippocampus and identified distinct classes of dysregulated genes during this process.

2018-11-13 | GSE115440 | GEO

A Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders

Project description:Perioperative neurocognitive disorder (PND) is a common neurological complication following surgery in elderly individuals and is closely associated with neuroinflammation and blood-brain barrier disruption. In this study, we investigated hippocampal transcriptomic alterations in aged mice subjected to tibial fracture surgery and evaluated the therapeutic effects of a neutrophil membrane-encapsulated Pd/hCeO2 nanoformulation (PCN). Bulk RNA sequencing was performed on hippocampal tissues collected from Control, PND, and PCN-treated mice. Differential gene expression and pathway enrichment analyses were conducted to identify molecular mechanisms involved in surgery-induced neuroinflammation and the therapeutic actions of PCN. These data provide a transcriptomic resource for understanding the pathogenesis of PND and the mechanisms underlying PCN-mediated neuroprotection.

2026-08-31 | GSE339068 | GEO

Maresin 1 attenuates neuroinflammation in a mouse model of perioperative neurocognitive disorders.

Project description: Not available

| S-EPMC6396737 | biostudies-literature

Excitation-inhibition shift in hippocampal of perioperative neurocognitive disorders: a single-cell landscape glance of pathological phenotype

Project description:Perioperative neurocognitive disorders (PND) are a common complication in elderly patients. PND seriously worsens the outcome of surgery, leads to a decline in the quality of life of patients after surgery, and increases the consumption of medical and social resources. However, at present, the pathogenesis of PND is unclear and the treatment is limited, so a comprehensive study on the pathogenesis of PND is urgently needed. We analyzed the hippocampus of 18-month-old PND mice by single-nucleus RNA sequencing, and obtained a landscape of cell type classification and phenotype. We revealed that PND induced abundant changes of crosstalk between inhibitory neurons and excitatory neurons. Through multi-dimensional analysis and electrophysiological experiments, We propose disturbance of neuronal excitation-inhibition (E/I) balance in hippocampus is a crucial mechanism of PND. More, by analyzing the trajectories of PND disease development, we suggest that PND-specific disease-associated astrocytes are different from known cognitive disease-associated astrocytes. We also showed changes of oligodendrocyte, OPCs and CNS associated macrophages in PND. Overall, our study propose that the excitation-inhibition imbalance which rely on crosstalk changes between excitatory and inhibitory neurons forms the basis of perioperative neurocognitive disorders.

2026-09-08 | GSE279516 | GEO

Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

Project description:Background: Perioperative neurocognitive disorders (PND), a postoperative cognitive dysfunction occurs more often in the elderly. The etiology of PND remains largely elusive. This study aims to understand the etiology in a mouse model with tibial fracture (a surgical trauma), by examining the transcriptome-wide response of hippocampus, a brain region that is tightly associated with memory formation. Methods: Mice at age of 7~8 months were randomly divided into two groups, surgery (tibial fracture) group and control (sham) group. At day (d) 1 after the surgical operation, hippocampal tissues were isolated and then subjected to RNA extraction and RNA sequencing (RNA-seq). Findings: Levels of respiratory complex related genes are significantly decreased in the brain of mice subjected to surgery. Consequently, the activities of multiple respiratory complexes and respiratory chain function is decreased in the hippocampus of mice with surgical operation. Interpretation: We here propose a novel mechanism of mitochondrial dysfunction in PND etiology, and also provide a potential therapeutic target for PND.

2022-02-09 | GSE178995 | GEO

Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

Project description:Hippocampus-based mitochondrial respiratory function decline is responsible for perioperative neurocognitive disorders

| PRJNA741808 | ENA

Perioperative administration of fucoidan induced immune-suppressive changes that resulted in no beneficiary outcomes in postoperative neurocognitive recovery

Project description:For many of the versatile functions of polysaccharides as natural ingredients in human foods, the immunomodulatory and anti-inflammatory activities of fucoidan, partly owing to its high sulfate content, attracted extensive attention in its potential application in cancer therapy as well as in prevention of neurodegeneration. In this study, we characterized the impact of long-term supplementation of Undaria pinnatifida-derived fucoidan on the gene expression and immune cell abundance in mouse PBMCs. Despite the significantly increased Th17 cells and activated NK cells, naïve B cells were substantially reduced in the PBMCs in fucoidan mice. Fucoidan supplementation induced prominent expression changes in genes associated with Th1/Th2 cell differentiation. Although fucoidan displayed a remarkable anti-inflammatory capacity in our mouse models, perioperative administration of fucoidan failed to show any noticeable beneficiary effect in relieving synaptic and cognitive dysfunction at the acute phase after surgery, which was believed to cause neurocognitive impairment by inducing neuroinflammation. Comparing with that of the mice with control diet, mitigated microglia activities including neuronal surveillance and phagocytosis were also observed in mice with perioperative administration of fucoidan. In addition, no influence on either basal level or surgery-induced oxidative stress was observed in mice with fucoidan supplementation. Given the complex features of inflammation as the first response to various detrimental situations, we proposed that the anti-inflammation potential of fucoidan was likely to induce an immune-suppressive change in the postoperative mouse brain and conferred unfavorable environment for the neurocognitive recovery at least at the acute phase after surgery.

2026-01-20 | GSE316433 | GEO

Identification and functional analysis of a potential key circRNA in aged mice with perioperative neurocognitive dysfunction

Project description:Perioperative neurocognitive dysfunction (PND) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of PND are not well known. Here we applied microarray analysis to identify circular RNAs (circRNAs) in hippocampus from a mouse model of PND and control mice. Then, the dysregulated circRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR). Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

2021-08-10 | GSE165798 | GEO

A Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders

Project description:A Neutrophil Membrane-Encapsulated Pd/hCeO2 Nanoformulation for Alleviating Age-Dependent Perioperative Neurocognitive Disorders

| PRJNA1496911 | ENA

Semaglutide Attenuates Neuroinflammation in Mice

Project description:Bulk RNA sequencing of the hippocampus from mice treated with semaglutide or vehicle control prior to lipopolysaccharide (LPS)-induced neuroinflammation.

2026-07-01 | E-MTAB-17123 | biostudies-arrayexpress

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