Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

The regulatory impact of RNA-binding proteins on microRNA targeting

ABSTRACT: The regulatory impact of RNA-binding proteins on microRNA targeting

PROVIDER: PRJNA475674 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR15108900.fastq.gz	Fastqsanger.gz
	SRR15108901.fastq.gz	Fastqsanger.gz
	SRR15108902.fastq.gz	Fastqsanger.gz
	SRR15108903.fastq.gz	Fastqsanger.gz
	SRR15108904.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 189

Similar Datasets

The regulatory impact of RNA-binding proteins on microRNA targeting

Project description:Argonaute is the primary mediator of metazoan miRNA targeting (MT). Among the currently identified >1,500 human RNA-binding proteins (RBPs), there are only a handful of RBPs known to enhance MT and several others reported to suppress MT, leaving the global impact of RBPs on MT elusive. In this study, we have systematically analyzed transcriptome-wide binding sites for 150 human RBPs and evaluated the quantitative effect of individual RBPs on MT efficacy. In contrast to previous studies, we show that most RBPs significantly affect MT and that all of those MT-regulating RBPs function as MT enhancers rather than suppressors, by making the local secondary structure of the target site accessible to Argonaute. Our findings illuminate the unappreciated regulatory impact of human RBPs on MT, and as these RBPs may play key roles in the gene regulatory network governed by metazoan miRNAs, MT should be understood in the context of co-regulating RBPs.

2021-07-09 | GSE115646 | GEO

The regulatory impact of RNA-binding proteins on microRNA targeting.

| S-EPMC8379221 | biostudies-literature

Transcriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting

Project description:This SuperSeries is composed of the following subset Series: GSE41241: Transcriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting [mRNA expression data] GSE41285: Transcriptome-wide miR-155 binding map reveals widespread non-canonical microRNA targeting [CLIP-seq data] Refer to individual Series

2012-11-09 | E-GEOD-41288 | biostudies-arrayexpress

Functional microRNA targeting without seed pairing

Project description:Functional microRNA targeting without seed pairing

| PRJNA1228674 | ENA

The biochemical basis of microRNA targeting efficacy

Project description:The biochemical basis of microRNA targeting efficacy

| PRJNA591816 | ENA

HDCA binding proteins

Project description:HDCA binding proteins

| PRJNA1006334 | ENA

TET proteins regulate Drosha expression and impact microRNAs in iNKT cells

Project description:DNA demethylases TET2 and TET3 play a fundamental role in thymic invariant natural killer T (iNKT) cell differentiation by mediating DNA demethylation of genes encoding for lineage specifying factors. Paradoxically, differential gene expression analysis revealed that significant number of genes were upregulated upon TET2 and TET3 loss in iNKT cells. This unexpected finding could be potentially explained if loss of TET proteins was reducing the expression of proteins that suppress gene expression. In this study, we discover that TET2 and TET3 synergistically regulate Drosha expression, by generating 5hmC across the gene body and by impacting chromatin accessibility. As Drosha is involved in microRNA biogenesis, we proceed to investigate the impact of TET2/3 loss on microRNAs in iNKT cells. We report that among the downregulated microRNAs are members of the Let7 family that downregulate in vivo the expression of the iNKT cell lineage specifying factor PLZF. Our data link TET proteins with microRNA expression and reveal an additional layer of TET mediated regulation of gene expression.

2024-08-30 | GSE267135 | GEO

The biochemical basis of microRNA targeting efficacy [1]

Project description:The biochemical basis of microRNA targeting efficacy [1]

| PRJNA588963 | ENA

The biochemical basis of microRNA targeting efficacy [5]

Project description:The biochemical basis of microRNA targeting efficacy [5]

| PRJNA592020 | ENA

The biochemical basis of microRNA targeting efficacy [2]

Project description:The biochemical basis of microRNA targeting efficacy [2]

| PRJNA591822 | ENA