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DNA methylation analysis of radiation-induced skin fibrosis of rats

ABSTRACT: DNA methylation analysis of radiation-induced skin fibrosis of rats

PROVIDER: PRJNA480034 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7479910_1.fastq.gz	Fastqsanger.gz
	SRR7479910_2.fastq.gz	Fastqsanger.gz
	SRR7479911_1.fastq.gz	Fastqsanger.gz
	SRR7479911_2.fastq.gz	Fastqsanger.gz
	SRR7479902_1.fastq.gz	Fastqsanger.gz

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DNA methylation analysis of radiation-induced skin fibrosis of rats

Project description:This study aims to compared the genome-wide DNA methylation status in radiation-induced fibrotic skin and adjacent normal tissues of rats by methylated DNA immunoprecipitation sequencing (MeDIP-Seq). Male Sprague-Dawley (SD) rats (4 weeks old) were irradiated with a single 45-Gy dose of irradiation was administered to the treatment area at a rate of 750 cGy/min using a 6-MeV electron beam accelerator (Clinac 2100EX, Varian Medical Systems, Inc., CA). Skin tissues from nonirradated skin areas and irradietd areas were collected and subjected to DNA methylation analysis by MeDIP.

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Project description:This study aims to compare the cell heterogeneity and mRNA expression between irradiated and non-irradiated rat skin tissues at the single cell level. In this study, the skin was isolated from rats with radiation or non-irradiated rats. Male Sprague Dawley (SD) rats (6 weeks of age) were used. For irradiation, the hair on the gluteal region of the rats was shaved using a razor. The animals were immobilized using adhesive tape on a plastic plate to minimize motion during radiation exposure. A 3-cm-thick piece of lead was used to shield the animals and localize the radiation field (3-4 cm). Irradiation was performed on the treatment area at a dose rate of 1000 cGy/min using a 6-MeV electron beam accelerator. Irradiated skin was taken on day 7, 14, 28 and 60 for RNA-seq, respectively. The control group of skin were collected from four rats without radiation and mixed for RNA-seq.

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