Dataset Information

Streptococcus thermophilus strain:CUL68

ABSTRACT: Streptococcus thermophilus strain:CUL68 Genome sequencing

PROVIDER: PRJNA482552 | ENA |

REPOSITORIES: ENA

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Project description:Pastick2009 - Genome-scale metabolic network of Streptococcus thermophilus (iMP429) This model is described in the article: Genome-scale model of Streptococcus thermophilus LMG18311 for metabolic comparison of lactic acid bacteria. Pastink MI, Teusink B, Hols P, Visser S, de Vos WM, Hugenholtz J. Appl. Environ. Microbiol. 2009 Jun; 75(11): 3627-3633 Abstract: In this report, we describe the amino acid metabolism and amino acid dependency of the dairy bacterium Streptococcus thermophilus LMG18311 and compare them with those of two other characterized lactic acid bacteria, Lactococcus lactis and Lactobacillus plantarum. Through the construction of a genome-scale metabolic model of S. thermophilus, the metabolic differences between the three bacteria were visualized by direct projection on a metabolic map. The comparative analysis revealed the minimal amino acid auxotrophy (only histidine and methionine or cysteine) of S. thermophilus LMG18311 and the broad variety of volatiles produced from amino acids compared to the other two bacteria. It also revealed the limited number of pyruvate branches, forcing this strain to use the homofermentative metabolism for growth optimization. In addition, some industrially relevant features could be identified in S. thermophilus, such as the unique pathway for acetaldehyde (yogurt flavor) production and the absence of a complete pentose phosphate pathway. This model is hosted on BioModels Database and identified by: MODEL1507180063. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Dataset Information

Streptococcus thermophilus strain:CUL68

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