Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional profiles of [ESI+]

ABSTRACT: Transcriptional profiles of [ESI+]

PROVIDER: PRJNA482670 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7588931_1.fastq.gz	Fastqsanger.gz
	SRR7588931_2.fastq.gz	Fastqsanger.gz
	SRR7588932_1.fastq.gz	Fastqsanger.gz
	SRR7588932_2.fastq.gz	Fastqsanger.gz
	SRR7588933_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Transcriptional profiles of [ESI+]

Project description:We profile the transcriptional landscapes associated with acquisition of [ESI+], a prion scaffolded by Snt1, a core component of the Set3C histone deacetylase. We find that acquisition of [ESI+] leads to expression of otherwise silent, heterochromatic loci, proposing a new molecular means by which silent transcriptional states might be reversed.

2020-02-29 | GSE117624 | GEO

Transcription Profiles of [ESI+] and Set3C loss of function

Project description:We report the transcriptional profiles of the [ESI+] prion, as well as snt1∆, set3∆, and hos2∆ diploid cells.

2020-02-29 | GSE128672 | GEO

Transcription Profiles of [ESI+] and Set3C loss of function

Project description:Transcription Profiles of [ESI+] and Set3C loss of function

| PRJNA528474 | ENA

Transcriptional profiles of sov mutant ovaries

Project description:Transcriptional profiles of sov mutant ovaries

| PRJNA454717 | ENA

Transcriptional profiles of male posterior amygdala

Project description:Transcriptional profiles of male posterior amygdala

| PRJNA637299 | ENA

Project description:Binding Profiles of [ESI+] Constituents

| PRJNA528459 | ENA

The transcriptional profiles of severe COVID-19

Project description:The transcriptional profiles of severe COVID-19

| PRJNA692106 | ENA

Prelimbic cortex to ventral tegmental area projection regulates early social isolation stress-potentiated heroin seeking in mice

Project description:Early-life adversities increase vulnerability to substance use disorders, which are characterized by persistent, uncontrollable drive to seek drugs, often leading to relapse. Previously, we reported that early social isolation (ESI) during adolescence potentiates heroin-seeking in mice. However, the underlying neurobiology remains unknown. Here, we found that ESI aggravated heroin-induced neuronal dysfunction in prelimbic cortex (PrL) to ventral tegmental area (VTA) projecting neurons. Activating PrL->VTA projection attenuated ESI-potentiated heroin seeking, alongside normalized neuronal function. RNA-seq revealed that ESI and heroin convergently altered genes regulating morphogenesis and metabolism, with Tmsb4x (thymosin β4) as a key gene. ESI and heroin interaction affected genes regulating cell cycle and DNA damage response, with Mcm3 and Mcm7 (minichromosome maintenance proteins 3/7) as hubs. PrL thymosin β4 infusion or CRISPR-Cas9-mediated PrL->VTA projection-specific Mcm3/7 knockdown attenuated ESI-potentiated heroin-seeking and neuronal hypofunction. Our study suggests that ESI-potentiated heroin relapse is associated with neuronal and transcriptional alterations in PrL->VTA projection.

2025-08-07 | GSE293281 | GEO

Single-cell transcriptional profiles in human skeletal muscle

Project description:Single-cell transcriptional profiles in human skeletal muscle

| PRJNA540859 | ENA

Transcriptional profiles of normal human mature B cells

Project description:Transcriptional profiles of normal human mature B cells

| PRJNA434224 | ENA