Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Affymetrix Gene Expression array data for Tcl1 mouse model samples

ABSTRACT: Affymetrix Gene Expression array data for Tcl1 mouse model samples

PROVIDER: PRJNA485294 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Affymetrix Gene Expression array data for Tcl1 mouse model samples

Project description:Tcl1 is known to be involved in survival, proliferation and differentiation of human lymphocytes and mouse embryonic stem cells. Loss of Tcl1 gene in the KO mouse model affects skin integrity inducing alopecia and ulcerations. The study used epidermal keratinocytes from wild type (WT), Tcl1 knock down (KO) and K14-driven TCL1 transgenic (TGKO) mouse models to investigate the role of Tcl1 gene in the skin homeostasis. Our data indicate that Tcl1 loss mainly induces a decrease in the gene expression of keratinocytes, which is largely rescued by K14-TCL1. GO analysis revealed Tcl1 to be involved in the proliferation and differentiation of mouse keratinocytes. Moreover, pathway analysis identifies growth factor and MAPK signaling to be highly implicated.

2018-08-10 | GSE118345 | GEO

Affymetrix SNP array data for meningioma samples

Project description:Affymetrix SNP array data for meningioma samples

| PRJNA1215284 | ENA

Affymetrix SNP array data for preeclampsia samples

Project description:Affymetrix SNP array data for preeclampsia samples

| PRJNA792399 | ENA

Affymetrix SNP array data for chicken samples

Project description:Affymetrix SNP array data for chicken samples

| PRJNA525994 | ENA

Expression data for Tcl1 tg mice compared to CD44ΔB Tcl1 tg mice

Project description:Tcl1 tg mice develop a chronic lymphocytic leukemia (CLL) -like disease. To investigate the contribution of the adhesion molecule CD44 to CLL pathophysiology, we developed a CD19Cre CD44flox/flox Tcl1 tg mouse with a B cell specific CD44 deficiency (CD44ΔB Tcl1 tg). We used the Clariom S mouse microarray from Affymetrix to investigate transcriptional differeneces between Tcl1 tg and CD44ΔB Tcl1 tg mice

2018-01-13 | GSE109121 | GEO

Affymetrix SNP array data for kidney transplant samples

Project description:Affymetrix SNP array data for kidney transplant samples

| PRJNA807291 | ENA

Affymetrix SNP array data for Cryptomeria japonica samples

Project description:Affymetrix SNP array data for Cryptomeria japonica samples

| PRJNA377702 | ENA

Affymetrix SNP array data for acute lymphoblastic leukemia samples

Project description:Affymetrix SNP array data for acute lymphoblastic leukemia samples

| PRJNA812429 | ENA

Affymetrix SNP array data for 14q12 deletion

Project description:Affymetrix SNP array data for 14q12 deletion