Project description:Whole genome transcriptional profiling was performed on conventional and germ free GATA4fl/flVillin cre+ and cre- littermate control mice to determine the role of GATA4 and the microbiota in mediating gene expression changes in the intestine.
Project description:Interventions: Group 1: Quantitative Expression Analysis of the proteom and gene Expression of Primary Tumor, normal tissue, and metastases
Primary outcome(s): Disease associated Proteins and Genes
Study Design: Allocation: ; Masking: ; Control: ; Assignment: ; Study design purpose: basic science
Project description:Tamoxifen-inducible conditional knockout (CKO) mice were generated to explore the function of Gcn1 in adult mice using the Cre/loxP system. To analyze the function of GCN1 in the intestinal epithelium, we compared the whole cell proteome of jejunum harvested from GCN1 CKO mice with that of wild-type mice.
Project description:We aimed to investigate the effects of maternal heat stress on the expression of differentilally expressed genes in th placenta, fetal duodenum and jejunum