Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [RNA-seq]

ABSTRACT: JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [RNA-seq]

PROVIDER: PRJNA487640 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7749860.fastq.gz	Fastqsanger.gz
	SRR7749861.fastq.gz	Fastqsanger.gz
	SRR7749862.fastq.gz	Fastqsanger.gz
	SRR7749863.fastq.gz	Fastqsanger.gz
	SRR7749864.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [UTX ChIP]

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [UTX ChIP]

| PRJNA550392 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells

| PRJNA487638 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells

| PRJNA550388 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ChIP-Seq]

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ChIP-Seq]

| PRJNA577412 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ATAC-seq]

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ATAC-seq]

| PRJNA487624 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ATAC-seq]

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ATAC-seq]

| PRJNA550391 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ChIP-seq]

Project description:JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [ChIP-seq]

| PRJNA487634 | ENA

JMJD3 and UTX Determine Fidelity and Lineage Specification of Human Neural Progenitor Cells [UTX ChIP]

Project description:Neurogenesis entails a highly orchestrated process from pluripotent to neural cell fates including progenitors (NPCs) and various neural subtypes. However, the precise epigenetic mechanisms underlying the fate decision remain poorly understood. Here, we deleted KDM6s (JMJD3 or/and UTX), the demethylases for H3K27me3, in human embryonic stem cells (hESCs) and show that their deletion does not impede NPC generation from hESCs. However, KDM6-deficient NPCs exhibit poor proliferation and fail to become neurons and glia. Mechanistically, KDM6 deficiency leads to H3K27me3 accumulation and blockade of DNA accessibility at loci essential for neurogenesis, thus hinder the fate transition from NPCs to neural subtypes. Our findings uncover an essential role of KDM6s in neurogenesis and highlight the contribution of individual epigenetic regulators in specifying lineage fidelity and fate decision during human development.

2019-12-02 | GSE133208 | GEO