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Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

ABSTRACT: Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

PROVIDER: PRJNA488661 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7771410.fastq.gz	Fastqsanger.gz
	SRR7771420.fastq.gz	Fastqsanger.gz
	SRR7771411.fastq.gz	Fastqsanger.gz
	SRR7771421.fastq.gz	Fastqsanger.gz
	SRR7771412.fastq.gz	Fastqsanger.gz

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Binding profile of the bZIP transcription factor, ATF-7, in C. elegans on pathogenic Pseudomonas aeruginosa

Project description:ChIP-seq of ATF-7::GFP from Wild Type or pmk-1 mutant animals exposed to either non-pathogenic E. coli OP50 or pathogenic P. aeruginosa PA14

2019-02-01 | GSE119293 | GEO

Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

Project description:RNA-seq of Wild Type (N2), pmk-1 or atf-7 mutant animals exposed to either non-pathogenic E. coli OP50 or pathogenic P. aeruginosa PA14

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C. elegans on pathogenic Pseudomonas aeruginosa

Project description:C. elegans on pathogenic Pseudomonas aeruginosa

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ATF-4 regulates C. elegans defense against pathogen infection

Project description:To gain molecular insights into how ATF-4 regulates C. elegans defense against bacterial infection, we employed RNA-seq to profile gene expression in atf-4(ok576) and WT animals with or without S. enterica infection.

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The GCN-2/eIF-2α/ATF-4 signaling pathway regulates C. elegans defense against pathogen infection

Project description:In response to external or endogenous insults, eukaryotic cells can activate a common adaptive pathway called the integrated stress response (ISR). The ISR reduces global protein translation but upregulates the expression of stress response proteins to either restore cellular homeostasis or, in case of severe or prolonged stress, promote cell death. The bZIP transcription factor ATF4 plays a deciding role in cellular fate upon ISR activation, but the precise mechanisms underlying such decision-making remain unclear. Although bacterial infection has previously been observed to induce the ISR, the effects of this pathway on bacterial pathogenesis and host defense are not well understood. The functions of ATF4 in this process remain even more elusive. Using the Caenorhabditis elegans model to explore the bacterial infection-induced ISR, we found that infection with Salmonella enterica induced the GCN-2/eIF-2α/ATF-4 signaling pathway to modulate host defense against the infection. More specifically, ATF-4 suppressed the expression of ribosomal proteins in response to S. enterica exposure, reducing worm survival against the pathogen. Because ribosomal proteins are directly involved in protein translation, our data revealed an important, novel mechanism by which ATF-4 mediates the reduction of global translation under stress by inhibiting the expression of ribosomal proteins. ATF-4 also inhibited mitochondrial electron transport in response to S. enterica infection, likely functioning to dampen infection-induced production of reactive oxygen species. Moreover, our transcriptomic analysis showed that ATF-4 regulated the expression of collagens, a group of proteins that are tightly linked to stress resistance and longevity. Overall, we have identified specific molecular mechanisms by which ATF-4 determines cell fate upon ISR activation, providing a mechanistic understanding of how the bacterial infection-induced ISR impacts host physiology.

2025-10-01 | PXD058186 | Pride

Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

Project description:Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

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C. elegans gene expression in response to the pathogenic P. aeruginosa strain PA14.

Project description:Analysis of differential gene expression in C. elegans adults exposed to three different bacteria: E. coli strain OP50, wild-type P. aeruginosa PA14 and gacA mutant PA14. Samples were analyzed at 4 hours and 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Keywords: Time course, response to pathogen infection

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Response of C. elegans immune pathway mutants to P. aeruginosa infection

Project description:Synchronized C. elegans cultures of three geontypes -- wildype N2, daf-2(e1370) and sma-6(wk7) -- were prepared using standard techniques (http://cmgm.stanford.edu/~kimlab/index_methods.html). Live young adult worms were split between NG plates pre-seeded with the non-pathogenic E. coli strain OP50 or the Pseudomonas aeruginosa clinical isolate PA14 and incubated at 25C for 4 or 24 hours before harvesting. This experiment was repeated at least three times on independent occasions. cDNA probes were prepared from experimental samples and from reference mRNA extracted from mixed stage wild type worms grown at 25C, and were labeled with Cy3 or Cy5, as indicated. A reference experiement design type is where all samples are compared to a common reference. Elapsed Time: Time Infection: Exposure to the non-pathogenic E. coli strain OP50 or to the pathogenic Pseudomonas aeruginosa strain PA14 Strain Name: C. elegans wildtype strain N2 or the immune pathway mutants daf-2(e1370) or sma-6(wk7) Keywords: reference_design

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Response of C. elegans immune pathway mutants to P. aeruginosa infection

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ATF-4 regulates C. elegans defense against pathogen infection

Project description:ATF-4 regulates C. elegans defense against pathogen infection

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