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Adipocytes induce melanoma plasticity by sensitizing cells to TGFb

ABSTRACT: Adipocytes induce melanoma plasticity by sensitizing cells to TGFb

PROVIDER: PRJNA489361 | ENA |

REPOSITORIES: ENA

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Adipocytes induce melanoma plasticity by sensitizing cells to TGFb

Project description:Transcriptome analysis of: 1- WM1716 melanoma cell line transfected with scrambled control or with miR-211. 2- WM3682 cell line mono-cultured or co-cultured with adipocytes.

2021-09-01 | GSE119478 | GEO

Naringenin and beta-carotene induce energy expenditure and insulin sensitizing genes in human white adipocytes

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Project description:PPARγ agonists induce biased signaling in human adipocytes

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RNA-seq data from human SGBS adipocytes differentiated with marine oxohexadecenoic acids

Project description:We recently isolated and identified (7E)-9-oxohexadec-7-enoic acid (1) and (10E)-9-oxohexadec-10-enoic acid (2) from the marine algae Chaetoceros karianus. Synthesis and biological characterization show that these are PPARα/γ dual agonists. Herein we report the gene expression data from human SGBS pre-adipocytes, stimulated to differentiate with 1, 2 or the classical PPARγ agonist rosiglitazone. The transcriptome analysis shows that both compounds induce anti-diabetic gene programs in adipocytes by upregulating insulin-sensitizing adipokines and repressing pro-inflammatory cytokines.

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DMD-TGFb-SETDB1

Project description:DMD-TGFb-SETDB1

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PPARγ agonists induce biased signaling in human adipocytes

Project description:Biased signaling and ligand bias, often referred to as functional selectivity or selective nuclear receptor modulation, have been reported for many nuclear receptor partial agonists over the past 20 years. However, whether differences in nuclear receptor signaling produced by partial and full agonists results from less intense partial agonist modulation, off-target effects, or biased signaling remains unclear. To determine whether biased signaling can occur through nuclear receptors we compare the transcriptional effects of two full agonists (which also favor different coactivator peptides) in human adipocytes. We also test the signaling effects of a partial agonist relative to full agonists. Furthermore, whether biased coactivator peptide recruitment translates to biased signaling in cells has not been determined. In a step towards this goal, we show that these same full agonists induce biased recruitment of 100-300 residue regions of coactivators containing all their nuclear receptor binding motifs. Together these data support the idea that nuclear receptor agonists can induce biased signaling through differences in coactivator recruitment.

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Tgfb in AT1 cells

Project description:Tgfb in AT1 cells

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Transcriptomics of Tgfb signaling

Project description:Transcriptomics of Tgfb signaling

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Expression Data from Bone Marrow Progenitor-Derived Adipocytes, White Adipocytes and Brown Adipocytes.

Project description:We have identified a population of adipocytes in fat tissue that arise from bone marrow-derived progenitor cells. We used microarrays to compare the global gene expression patterns of the bone marrow progenitor-derived adipocytes as well as conventional white and brown adipocytes to evaluate the relationship between these adipocyte subpopulations. Gonadal fat tissue (for white adipocytes) and intrascapular fat tissue (for brown adipocytes) was digested with collagenase and adipocytes were recovered by centrifugation/flotation. Bone marrow derived adipocytes were isolated from the adipocyte fraction of gonadal fat tissue from mice receiving bone marrow tranplants from donors expressing either green fluorescent protein (GFP) or beta-galactosidase (LacZ) by flow cytometry.

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