Project description:As part of the West Virginia Chemical Spill research program, NTP evaluated three chemicals that were spilled into the Elk Rever in West Virginia for their ability to cause toxicity or biological changes in a short-term toxicogenomic study
Project description:Genome-wide expression assay of S. alterniflora individuals from populations (4 from Louisiana, 2 from Mississippi) either exposed or unexposed to the Deepwater Horizon oil spill
Project description:Human exposure to chemically diverse hazardous substances has increased the need for human-relevant models for toxicity assessment. In this study, we performed bulk RNA sequencing of four human epithelial cell lines representing major exposure-relevant tissues: HIEC-6 intestinal epithelial cells, HL7702 hepatic epithelial cells, BEAS-2B bronchial epithelial cells, and HaCaT keratinocytes. Cells were exposed to nine hazardous chemicals, including DBP, DINCH, BPA, BPS, PFOA, PFTeDA, DEHP, NiCl2, and AlCl3, at cell line-specific IC01 concentrations, with vehicle controls included for each cell line. Biological triplicates were generated for all conditions, resulting in 120 samples. Comparative transcriptomic analysis was used to evaluate shared and cell line-dependent responses to hazardous chemical exposure. The dataset provides a toxicogenomic resource for investigating chemical-induced molecular perturbations across human epithelial models.
Project description:This SuperSeries is composed of the following subset Series: GSE13423: Microarray Analysis of Toxicogenomic Effects of Sodium Hypochlorite on Mycobacterium bovis BCG GSE14272: Microarray Analysis of Toxicogenomic Effects of Hydrogen Peroxide on Mycobacterium bovis BCG Refer to individual Series