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Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

ABSTRACT: Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

PROVIDER: PRJNA493080 | ENA |

REPOSITORIES: ENA

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Expression data of miRNAs and mRNAs from the fetal rats with anorectal malformations

Project description:many dysregulated mRNAs as the primary factor could be play an important role in the development of anorectum we used microarrays to reveal the global programme of gene expression underlying the development of anorectal malformations.

2018-09-26 | GSE120445 | GEO

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

Project description:many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17.High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

2024-11-29 | GSE190332 | GEO

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Many dysregulated miRNAs and lncRNAs as the primary factor could be play an important role in the development of lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17. High-throughput sequencing was utilized to reveal the expression of non-coding RNAs underlying the development of anorectal malformations.

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Expression data of circRNAs from the fetal rats with anorectal malformations

Project description:Anorectal malformations (ARMs) are among the most common congenital terminal digestive tract malformations. Circular RNAs (circRNAs), a novel type of endogenous non-coding RNAs, play roles in the development of the digestive system; however, their contributions to the pathogenesis of ARMs are not well-established. Many dysregulated circRNAs as the primary factor could play an important role in the development of anorectum. We used high-throughput sequencing to reveal the regulatory mechanism of gene expression underlying the development of anorectal malformations. These results provide original insight into the roles of circRNAs in ARMs and provide a valuable resource for further analyses of molecular mechanisms and signaling networks.

2021-05-06 | GSE159306 | GEO

Expression data of circRNAs from the fetal rats with anorectal malformations

Project description:Expression data of circRNAs from the fetal rats with anorectal malformations

| PRJNA668340 | ENA

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 19

| PRJNA786758 | ENA

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic day 17

| PRJNA786759 | ENA

Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

Project description:Expression data of miRNAs and lncRNAs from the lumbosacral spinal cord of fetal rats with anorectal malformations in embryonic days 17 and 19

| PRJNA786756 | ENA

Expression pattern of Wif1 and <b>β</b>-catenin during development of anorectum in fetal rats with anorectal malformations.

Project description:PurposeThis study was performed to investigate the expression pattern of Wnt inhibitory factor 1 (Wif1) and β-catenin during anorectal development in normal and anorectal malformation (ARM) embryos and the possible role of Wif1 and β-catenin in the pathogenesis of ARM.MethodsARM was induced with ethylenethiourea on the 10th gestational day in rat embryos. Cesarean deliveries were performed to harvest the embryos. The expression pattern of Wif1 and β-catenin protein and mRNA was evaluated in normal rat embryos (n = 288) and ARM rat embryos (n = 306) from GD13 to GD16 using immunohistochemical staining, Western blot, and real time RT-PCR.ResultsImmunohistochemical staining revealed that in normal embryos Wif1 was constantly expressed in the cloaca from GD13 to GD16. On GD13 and GD14, Wif1-immunopositive cells were extensively expressed in the cloaca. On GD15, the expression of Wif1 were mainly detected on the very thin anal membrane. In ARM embryos, the epithelium of the hindgut and urorectal septum demonstrated faint immunostaining for Wif1 from GD14 to GD16. Western blot and real time RT-PCR revealed that Wif1 and β-catenin protein and mRNA expression level was significantly decreased in the ARM groups compared with the normal group on GD14 and GD15 (p < 0.05).ConclusionsThis study demonstrated that the expression pattern of Wif1 and β-catenin was disrupted in ARM embryos during anorectal morphogenesis, which demonstrated that downregulation of Wif1 and β-catenin at the time of cloacal separation into the primitive rectum and urogenital septum might related to the development of ARM.

| S-EPMC5836566 | biostudies-literature

Prenatal screening for miRNAs in fetal diseases

Project description:Distinct miRNA expression patterns may reflect anomalies related to fetal malformations such as spinal bifida (SB) or congenital diaphragmatic hernia (CDH), which could shed light on novel pathomechanism determination and subsequent diagnostic significance evaluation. The aim of this study was to determine the miRNA maternal expression profile in plasma and amniotic fluid samples of women carrying fetuses with SB and CDH.

2024-03-20 | GSE242364 | GEO

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