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Differentially expressed miRNA in recurrent implantation failure (RIF)

ABSTRACT: Differentially expressed miRNA in recurrent implantation failure (RIF)

PROVIDER: PRJNA496396 | ENA |

REPOSITORIES: ENA

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Differentially expressed miRNA in recurrent implantation failure (RIF)

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Expression data of endometrium from patients with recurrent implantation failure and normal women

Project description:Recurrent implantation failure (RIF) is a challenge in the field of reproductive medicine. The dysfunction of endometrium is one of the pathogenesis of implantation failure. We used microarrays to detail the global programme of gene expression underlying the molecular pathogenesis of implantation failure.

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Transcriptome-wide N6-methyladenosine modification profiling in patients with recurrent implantation failure (RIF)

Project description:Purpose:using m6A modified RNA immunoprecipitation sequence (m6A-seq), to establish the m6A methylation transcription profiles in recurrent implantation failure (RIF). Methods: GenSeq® Low Input Whole RNA Library Prep Kit (GenSeq, Inc.) was used to construct RNA libraries for IP and input samples by following the manufacturer's instructions. The library quality was evaluated using Agilent 2100 bioanalyzer and then sequenced in a NovaSeq platform (Illumina 6000). Result:using m6A modified RNA immunoprecipitation sequence (m6A-seq), methylated sites in mRNA,lncRNA and circRNA are identified. Conclusions: Our study revealed the m6A methylation landscape by MERIP sequencing.

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Project description:We aimed to identify altered biological processes in the endometrium that may be potential markers of receptive endometrium. RNA expression profiling of the endometrium during the window of implantation was performed in patients with Recurrent Implantation Failure (RIF) versus fertile controls.

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Glandular Epithelium and Unexplained Recurrent Implantation Failure

Project description:Recurrent Implantation Failure (RIF), which refers to the failure to achieve clinical pregnancy following embryo transfer repetitively, continues to be a major obstacle in assisted reproductive technology. RIF could be caused by many disease and most of which is related to abnormal endometrium. However, unexplained RIF is a special situation which puzzles doctors and patients. We use single-cell RNA sequencing to investigate the endometrial mechanism in unexplained RIF because the complicated environment of endometrium. Our results showed endometrium of RIF had higher levels of proliferation and activation of cytotoxic CD8+ T cells, which reject embryo implantation. Furthermore, glandular epithelium exhibits the highest metabolic activity, and it showed abnormal glycolysis and lower lactic acid production in the RIF, which was characterized by lower expression of genes related to glucose intake (SLC12A1), glucose metabolism (ALDOA), lactic acid production (LDHA) and output (SLC16A4) compared with the counterpart in the normal. The suppressive effect of lactic acid on CD8+ T cells was verified in vivo and vitro. We propose that RIF endometrium has not established the immune tolerance to embryo, which was attributed the abnormal glycolysis and lower lactic acid production in glandular epithelium.

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