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Effect of high-fat diet on hepatic DNA methylation in SM/J mice

ABSTRACT: Effect of high-fat diet on hepatic DNA methylation in SM/J mice

PROVIDER: PRJNA503129 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8139210_1.fastq.gz	Fastqsanger.gz
	SRR8139210_2.fastq.gz	Fastqsanger.gz
	SRR8139211_1.fastq.gz	Fastqsanger.gz
	SRR8139211_2.fastq.gz	Fastqsanger.gz
	SRR8139202.fastq.gz	Fastqsanger.gz

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Effect of high-fat diet on hepatic gene expression in SM/J mice

Project description:Effect of high-fat diet on hepatic gene expression in SM/J mice

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Effect of high-fat diet on hepatic gene expression in SM/J mice

Project description:We identified 4,356 genes with expression differences associated with a high-fat diet, with 184 genes exhibiting a sex-by-diet interaction. Dietary fat dysregulated several pathways, such as cytokine-cytokine receptor interaction, chemokine signaling, and oxidative phosphorylation. Grant: Funding source: American Heart Association Grant number: 16PRE26420105 Title: The effect of maternal over-nutrition on obesity, epigenetics, and gene expression Awarded to Madeline Keleher

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Effect of high-fat diet on hepatic DNA methylation in SM/J mice

Project description:We identified differentially methylated regions across the genome in the liver associated with a high-fat diet. Grant: Funding source: American Heart Association Grant number: 16PRE26420105 Title: The effect of maternal over-nutrition on obesity, epigenetics, and gene expression Awarded to Madeline Keleher

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Effect of a probiotic goat milk on the hepatic proteomic profile of mice fed a high-fat diet

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Hepatic transcriptome changes in testosterone-deficient pigs fed a high-fat diet

Project description:To gain insight into the role of testosterone in modulating hepatic fat accumulation, we collected liver tissues from high fat diet-fed intact male pigs, castrated male pigs, and castrated male pigs with testosterone replacement. RNA-Seq was employed to profile hepatic gene expression in pigs with different testosterone levels. Liver mRNA profiles of intact male pigs fed a HFC diet, castrated male pigs fed a HFC diet, and castrated male pigs treated with testosterone fed a HFC diet were generated by deep sequencing, using Illumina HiSeq 2000.

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High-Low Fat Diet/Strain Experiment

Project description:Males and females from each SM/J and LG/J were placed on either a low-fat diet or high-fat diet immediately after weaning until 20 weeks of age. At 20 weeks, mice were sacrificed in late morning after a four-hour fast and liver tissue was collected from 4 males and 4 females from each strain and diet.

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Project description:Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls. Hepatic Xbp1 deficient mice or flox controls were fed either regular chow or a high fat diet (n=4). Samples from each cohort were pooled into two replicates.

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