Project description:SKOV3 ovarian cancer cells have high basal autophagy levels and were used as a model cell line to enable knockdown of autophagy genes and study the changes of DNA copy number as a consequence of impaired autophagy.
Project description:To investigate the function of STXBP6 in the regulation of ovarian cancer, we established SKOV3 cell lines in which STXBP6 gene has been knocked down by shRNA.