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Hepatic transcriptome profiling of liver-specific Elovl6 knockout mice fed a high-sucrose diet

ABSTRACT: Hepatic transcriptome profiling of liver-specific Elovl6 knockout mice fed a high-sucrose diet

PROVIDER: PRJNA508938 | ENA |

REPOSITORIES: ENA

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Hepatic transcriptome profiling of liver-specific Elovl6 knockout mice fed a high-sucrose diet

Project description:Elovl6 is a member of mammalian fatty acid elongase that is responsible for converting C16 saturated and monounsaturated fatty acids into C18 species. To understand the role of Elovl6 in liver, we generated liver-specific Elovl6 knockout mice (Albumin-Cre;Elovl6 fl/fl C57BL/6J). The goal of this experiment was to determine effects of hepatocyte Elovl6 deficiency on the murine liver transcriptome under lipogenic condition.

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Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet

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Project description:To assess the effect of steatosis and oxidative stress on progression of liver fibrosis, we have employed whole genome microarray expression profiling as a discovery platform to identify genes that are related with oxidative stress- and steatosis-induced hepatic fibrogenesis. When wild type mice were fed high-fat/high-sucrose diet for 24 weeks, expression of 69 genes was changed more than 10-fold compared with wild type animals fed normal diet, 11 of which were categorized to lipid metabolic process. Moreover, expression of 208 genes showed more than 5-fold changes in Tet-mev-1 mice fed high-fat/high-sucrose diet compared with the same transgenic animals fed normal diet, and gene ontology analyses indicated significant changes in chemokine activity and chemokine receptor binding as well as defense and immune responses.

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Changes in hepatic transcriptome profile in α4β7 mAb-treated Western diet-fed mice

Project description:Hepatic transcriptome of junctional adhesion molecule A knockout, F11r–/– mice fed a Western diet (WD) for eight weeks. A cohort of WD-fed mice were treated with IgG or α4β7 mAb for four weeks starting at week four following initiation of the WD.

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Transcriptomic profiles of white adipose tissue and liver in rats fed either a high-sucrose diet or high-sucrose diet combined with quercetin treatment

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