Project description:RNA-seq of Klebsormidium nitens NIES-2285 in the presence of IAA (NIES-2285 strain was taxonomically reclassified from K. flaccidum)

| PRJDB4958 | ENA

Klebsormidium nitens strain:NIES-2285

Project description:genome sequence project of a filamentous terrestrial alga Klebsormidium nitens NIES-2285 (NIES-2285 strain was taxonomically reclassified from K. flaccidum)

| PRJDB718 | ENA

Klebsormidium flaccidum genome reveals primary factors for plant terrestrial adaptation.

Project description:The colonization of land by plants was a key event in the evolution of life. Here we report the draft genome sequence of the filamentous terrestrial alga Klebsormidium flaccidum (Division Charophyta, Order Klebsormidiales) to elucidate the early transition step from aquatic algae to land plants. Comparison of the genome sequence with that of other algae and land plants demonstrate that K. flaccidum acquired many genes specific to land plants. We demonstrate that K. flaccidum indeed produces several plant hormones and homologues of some of the signalling intermediates required for hormone actions in higher plants. The K. flaccidum genome also encodes a primitive system to protect against the harmful effects of high-intensity light. The presence of these plant-related systems in K. flaccidum suggests that, during evolution, this alga acquired the fundamental machinery required for adaptation to terrestrial environments.

| S-EPMC4052687 | biostudies-literature

Klebsormidium crenulatum strain:SAG 2415

Project description:Klebsormidium crenulatum strain:SAG 2415 Transcriptome or Gene expression

| PRJNA255200 | ENA

Klebsormidium nitens strain:NIES-2285

Project description:CAGE-seq of Klebsormidium nitens NIES-2285

| PRJDB15075 | ENA

Chemometrics-Assisted Identification of Anti-Inflammatory Compounds from the Green Alga Klebsormidium flaccidum var. zivo.

Project description:The green alga Klebsormidium flaccidum var. zivo is a rich source of proteins, polyphenols, and bioactive small-molecule compounds. An approach involving chromatographic fractionation, anti-inflammatory activity testing, ultrahigh performance liquid chromatography-mass spectrometry profiling, chemometric analysis, and subsequent MS-oriented isolation was employed to rapidly identify its small-molecule anti-inflammatory compounds including hydroxylated fatty acids, chlorophyll-derived pheophorbides, carotenoids, and glycoglycerolipids. Pheophorbide a, which decreased intracellular nitric oxide production by inhibiting inducible nitric oxide synthase, was the most potent compound identified with an IC50 value of 0.24 µM in lipopolysaccharides-induced macrophages. It also inhibited nuclear factor kappaB activation with an IC50 value of 32.1 µM in phorbol 12-myristate 13-acetate-induced chondrocytes. Compared to conventional bioassay-guided fractionation, this approach is more efficient for rapid identification of multiple chemical classes of bioactive compounds from a complex natural product mixture.

| S-EPMC7179104 | biostudies-literature

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