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Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

ABSTRACT: Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

PROVIDER: PRJNA515327 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8446370.fastq.gz	Fastqsanger.gz
	SRR8446371.fastq.gz	Fastqsanger.gz
	SRR8446372.fastq.gz	Fastqsanger.gz
	SRR8446373.fastq.gz	Fastqsanger.gz
	SRR8446374.fastq.gz	Fastqsanger.gz

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Similar Datasets

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

Project description:In this study, use of a gene-targeted mouse model that is defective for pRb-condensin II interactions, Rb1L, has revealed instances where condensin II localization in interphase nuclei is dependent on pRb. Condensin II binding overlaps significantly with marks of active chromatin, and is enriched at the promoters of genes, including closely spaced divergent promoters. Interestingly, there are some bidirectional promoters where condensin II binds in an pRb-dependent manner and transcription of only one of the two genes is upregulated in Rb1L/L MEFs, suggesting the pRb-condensin II complex may be acting as a repressor or an insulator at distinct genomic locations to influence transcription. Chromatin conformations at these locations demonstrated that the pRb-condensin II complex may be responsible for maintaining more static, long-range interactions. In addition, pRb also recruits TFIIIC, another condensin II interactor, to many genomic loci. These recently discovered non-canonical transcriptional functions of the pRb-condensin II complex may represent an additional mechanism of pRb-mediated tumor suppression.

2019-11-04 | GSE125139 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

2019-11-04 | GSE125127 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [RNA-seq]

2019-11-04 | GSE125147 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

2019-11-04 | GSE125148 | GEO

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

| PRJNA515324 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [4C-seq]

| PRJNA515313 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [ChIP-seq]

| PRJNA515322 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

Project description:Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes [expression array]

| PRJNA515326 | ENA

Condensin II is recruited to promoters by pRb and regulates expression of divergently paired genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-11-04 | GSE125149 | GEO

Molecular mechanism targeting condensin for chromosome condensation.

Project description:Faithful chromosome segregation requires packaging of the genome on both global and local scales. Condensin plays a crucial role at pericentromeres to resist spindle forces and ensure the oriented attachment of kinetochores to microtubules at mitosis. Here we demonstrate that budding yeast condensin is recruited to pericentromeres through a direct interaction between its Ycg1 subunit and the pericentromeric adaptor protein, shugoshin (Sgo1). We identify a Short Linear Motif (SLiM), termed CR1, within the C-terminal region of Sgo1 which inserts into a conserved pocket on Ycg1. Disruption of this interface abolishes the Sgo1-condensin interaction, prevents condensin recruitment to pericentromeres and results in defective sister kinetochore biorientation in mitosis. Similar motifs to CR1 are found in known and potential condensin binding partners and the Ycg1 binding pocket is broadly conserved, including in mammalian CAP-G proteins. Overall, we uncover the molecular mechanism that targets condensin to define a specialized chromosomal domain.

2024-12-10 | PXD056649 | Pride

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