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Histone demethylase KDM4A-mediated promotion of PAF1/NFATC2 expression is required for oncogenesis in MLL-AF9 acute myeloid leukemia

ABSTRACT: Histone demethylase KDM4A-mediated promotion of PAF1/NFATC2 expression is required for oncogenesis in MLL-AF9 acute myeloid leukemia

PROVIDER: PRJNA515937 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8460390.fastq.gz	Fastqsanger.gz
	SRR8460391.fastq.gz	Fastqsanger.gz
	SRR8460401.fastq.gz	Fastqsanger.gz
	SRR8460392.fastq.gz	Fastqsanger.gz
	SRR8460402.fastq.gz	Fastqsanger.gz

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Histone demethylase KDM4A-mediated promotion of PAF1/NFATC2 expression is required for oncogenesis in MLL-AF9 acute myeloid leukemia [ChIP-seq]

Project description:In this study we identified the histone demethylase KDM4A as an essential and selective regulator of AML oncogenic potential. ChIPseq was used to identify KDM4A bound genes and follow changes in H3K9me2/3 and H3K27me3 following KDM4A knockdown in MLL-AF9 human AML THP-1 cells

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Project description:Histone demethylase KDM4A-mediated promotion of PAF1/NFATC2 expression is required for oncogenesis in MLL-AF9 acute myeloid leukemia [ChIP-seq]

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